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1. WO2005054215 - 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS

Publication Number WO/2005/054215
Publication Date 16.06.2005
International Application No. PCT/EP2004/012953
International Filing Date 16.11.2004
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/426 (2006.01)
A61K 31/427 (2006.01)
C07D 277/20 (2006.01)
C07D 417/06 (2006.01)
CPC
A61K 31/426
C07D 277/20
C07D 277/42
C07D 277/54
C07D 417/06
Applicants
  • ACTELION PHARMACEUTICALS LTD [CH/CH]; Gewerbestrasse 16 CH-4123 Allschwil, CH (AllExceptUS)
  • BOLLI, Martin [CH/CH]; CH (UsOnly)
  • SCHERZ, Michael [US/CH]; CH (UsOnly)
  • MUELLER, Claus [DE/DE]; DE (UsOnly)
  • MATHYS, Boris [CH/CH]; CH (UsOnly)
  • BINKERT, Christoph [CH/CH]; CH (UsOnly)
Inventors
  • BOLLI, Martin; CH
  • SCHERZ, Michael; CH
  • MUELLER, Claus; DE
  • MATHYS, Boris; CH
  • BINKERT, Christoph; CH
Agents
  • HOFMANN, Dieter; Actelion Pharmaceuticals Gewerbestrasse 16 CH-4123 Allschwil, CH
Priority Data
PCT/EP03/1307221.11.2003EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS
(FR) DERIVES DE 5-(BENZ-(Z)-YLIDENE)-THIAZOLIDINE-4-ONE UTILISES COMME AGENT IMMUNODEPRESSEURS
Abstract
(EN)
The invention relates to pharmaceutical compositions containing at least one 5- (benz- (Z) -ylidene-thiazolidin-4-one derivative (I), to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
(FR)
L'invention concerne des compositions pharmaceutiques contenant au moins un dérivé de thiazoline-4-one (I), utilisées pour prévenir ou traiter des troubles associés à un système immunitaire activé. L'invention concerne en outre de nouveaux dérivés de thiazoline-4-one, s'utilisant notamment comme composés pharmaceutiquement actifs. Lesdits composés agissent en particulier comme agents immunodépresseurs. Formule générale (I)
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