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1. WO2005046978 - METHOD OF MANUFACTURING NUCLEATED MOLDING

Publication Number WO/2005/046978
Publication Date 26.05.2005
International Application No. PCT/JP2004/016759
International Filing Date 11.11.2004
IPC
A61J 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
10into the form of compressed tablets
B30B 11/34 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
30PRESSES
BPRESSES IN GENERAL; PRESSES NOT OTHERWISE PROVIDED FOR
11Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses or tabletting presses
34for coating articles, e.g. tablets
CPC
A61J 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
06into the form of pills, lozenges or dragees
A61J 3/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
07into the form of capsules or similar small containers for oral use
A61J 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
10into the form of compressed tablets
B30B 11/00
BPERFORMING OPERATIONS; TRANSPORTING
30PRESSES
BPRESSES IN GENERAL
11Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
B30B 11/02
BPERFORMING OPERATIONS; TRANSPORTING
30PRESSES
BPRESSES IN GENERAL
11Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
02using a ram exerting pressure on the material in a moulding space
B30B 11/34
BPERFORMING OPERATIONS; TRANSPORTING
30PRESSES
BPRESSES IN GENERAL
11Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
34for coating articles, e.g. tablets
Applicants
  • 株式会社三和化学研究所 SANWA KAGAKU KENKYUSHO CO., LTD. [JP]/[JP] (AllExceptUS)
  • 株式会社菊水製作所 KIKUSUI SEISAKUSHO LTD. [JP]/[JP] (AllExceptUS)
  • 尾関 有一 OZEKI, Yuichi [JP]/[JP] (UsOnly)
  • 泉 賢太郎 IZUMI, Kentaro [JP]/[JP] (UsOnly)
  • 原田 憲二 HARADA, Kenji [JP]/[JP] (UsOnly)
Inventors
  • 尾関 有一 OZEKI, Yuichi
  • 泉 賢太郎 IZUMI, Kentaro
  • 原田 憲二 HARADA, Kenji
Agents
  • 赤澤 一博 AKAZAWA, Kazuhiro
Priority Data
2003-38450214.11.2003JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD OF MANUFACTURING NUCLEATED MOLDING
(FR) PROCEDE POUR LA FABRICATION D'UN MOULAGE A NOYAU
(JA) 有核成型品の製造方法
Abstract
(EN) A method of manufacturing a molding containing a core by using a compression molding means with a vertical double-structured pestle, comprising steps for supplying and filling a core molding material and an outer layer molding material, a step for compression-molding the core molding material and/or the outer layer molding material, and a step for compression-molding the complete molding containing the core. In the method, the step for supplying and filling the outer layer molding material after the step for supplying and filling the core molding material is performed until the tip of a lower central pestle is brought into the projected state from the tip of a lower outer pestle, and the step for compression-molding the complete molding is performed with the tip of the lower central pestle aligned with the tip of the lower outer pestle. Thus, such an effect that the strength of the outer layer of the side face portion of the molding is increased and/or such an effect that the outer layer molding material supplied and filled after the core molding material supplying and filling step is passed to the lower side of a temporary core molding and a nucleated molding can be manufactured in two times of molding material supplying and filling step can be expected by this manufacturing method.
(FR) L'invention concerne un procédé pour la fabrication d'un moulage à noyau à l'aide d'un moyen de moulage par compression avec un pilon vertical à structure double. Ledit procédé comporte des étapes consistant à fournir et à remplir le matériau de moulage de formation de noyau et un matériau de moulage de formation de couche, une étape consistant à mouler par compression le matériau de moulage de formation de noyau et/ou le matériau de moulage de formation de couche et une étape consistant à mouler par compression le moulage entier comprenant le noyau. Selon le procédé, l'étape consistant à fournir et à remplir le matériau de moulage de formation de couche suivant l'étape consistant à fournir et à remplir le matériau de moulage de formation de noyau est exécutée jusqu'à ce que la pointe d'un pilon central inférieur soit amenée en position sortie de la pointe d'un pilon externe inférieur et l'étape consistant à mouler par compression le moulage entier est exécutée avec la pointe du pilon central inférieur alignée avec la pointe du pilon externe inférieur. De cette manière, la résistance de la couche externe de la section à la face latérale du moulage est améliorée et/ou le matériau de moulage de formation de couche, fournit et rempli après l'étape consistant à fournir et à remplir le matériau de moulage de formation de noyau, est passé au côté inférieur d'un moulage de noyau temporaire et un moulage à noyau peut être fabriqué en deux étapes consistant à fournir et à remplir le matériau de moulage à l'aide de ce procédé de fabrication.
(JA) 上下2重構造杵を有する圧縮成型手段を用い、核用成型材料と外層用成型材料のそれぞれの供給充填工程と、核用成型材料及び/又は外層用成型材料の圧縮成型工程と、核を含有する成型品全体の圧縮成型工程とを含む、核を有する成型品の製造方法において、核用成型材料の供給充填工程の後の外層用成型材料の供給充填工程を最終的に下中心杵杵先が下外杵杵先より突出した状態になるまで行い、更に下中心杵杵先と下外杵杵先とを揃えて成型品全体の圧縮成型工程を実施する。本法により、成型品側面部分の外層の強度を上げる効果、及び/又は、核用成型材料の供給充填工程の後で供給充填された外層用成型材料が核仮成型品の下側に回り込み、2回の成型材料の供給充填工程で有核成型品の製造を可能とする効果が期待できる。
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