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1. WO2005040167 - NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES

Publication Number WO/2005/040167
Publication Date 06.05.2005
International Application No. PCT/SE2004/001522
International Filing Date 21.10.2004
IPC
C07D 471/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • BLADH, Håkan [SE]/[SE] (UsOnly)
  • CONNOLLY, Stephen [GB]/[GB] (UsOnly)
  • DYKE, Hazel Joan [GB]/[GB] (UsOnly)
  • LISIUS, Annea [SE]/[SE] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
  • SHAMOVSKY, Igor [CA]/[SE] (UsOnly)
  • VAN DEN HEUVEL, Marco [NL]/[GB] (UsOnly)
Inventors
  • BLADH, Håkan
  • CONNOLLY, Stephen
  • DYKE, Hazel Joan
  • LISIUS, Annea
  • PRICE, Stephen
  • SHAMOVSKY, Igor
  • VAN DEN HEUVEL, Marco
Agents
  • ASTRAZENECA
Priority Data
0302811-523.10.2003SE
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES
(FR) NOUVEAUX DIAZASPIROALCANES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES INDUITES PAR CCR8
Abstract
(EN) The invention provides compounds of general formula. wherein A, B, W, X, Y, Z, D, E, R1 and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
(FR) L'invention concerne des composés représentés par la formule générale (I). Dans cette formule A, B, W, X, Y, Z, D, E, R1 et n sont définis comme dans la description. L'invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique.
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