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1. (WO2005038465) ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/038465 International Application No.: PCT/EP2004/012185
Publication Date: 28.04.2005 International Filing Date: 07.10.2004
IPC:
A61K 31/498 (2006.01) ,G01N 33/74 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
498
Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
Applicants: NESBIT, Mark[GB/FR]; FR (UsOnly)
SPADA, Alfred, P.[US/US]; US (UsOnly)
HE, Wei[US/US]; US (UsOnly)
MYERS, Michael, R.[US/US]; US (UsOnly)
CENTELION[FR/FR]; 72-82 rue Léon Geffroy F-94400 Vitry Sur Seine, FR (AllExceptUS)
AVENTIS PHARMACEUTICALS INC.[US/US]; Route 202-206, P.O. Box 6800, Mail Code EMC-G1 Bridgewater, NJ 08807-0800, US (AllExceptUS)
Inventors: NESBIT, Mark; FR
SPADA, Alfred, P.; US
HE, Wei; US
MYERS, Michael, R.; US
Agent: LECCA, Patricia; CENTELION 72-82 rue Léon Geffroy F-94400 Vitry sur Seine, FR
Priority Data:
60/508,85907.10.2003US
Title (EN) ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS
(FR) METHODES ANTIVASCULAIRES ET ANTIPROLIFERATION, THERAPIES ET COMBINAISONS METTANT EN APPLICATION DES INHIBITEURS SPECIFIQUES DE TYROSINE KINASE
Abstract:
(EN) This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature vasculature within chemotherapeutic refractory tumors, pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cell proliferation, and particularly treatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer, and human leukemias, such as CML, AML or ALL.
(FR) L'invention concerne des inhibiteurs puissants de tyrosine kinase seuls ou en combinaison synergique avec des agents antiangiogènes ou chimiothérapiques afin d'éliminer la vascularisation mature dans des tumeurs réfractaires à la chimiothérapie, des compositions pharmaceutiques contenant ces composés, ainsi que l'utilisation de ces derniers pour traiter un patient souffrant de troubles/états induits par une prolifération cellulaire, ou sujet à ces troubles, et, plus particulièrement, pour le traitement du cancer du cerveau, des ovaires, du pancréas ou de la prostate, des leucémies humaines, telles que CML, AML ou ALL.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)