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Machine translation
1. (WO2005037826) SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/037826    International Application No.:    PCT/US2004/033945
Publication Date: 28.04.2005 International Filing Date: 15.10.2004
IPC:
C07D 207/08 (2006.01), C07D 211/32 (2006.01), C07D 213/50 (2006.01), C07D 241/04 (2006.01), C07D 401/06 (2006.01), C07D 401/08 (2006.01), C07D 403/08 (2006.01), C07D 405/08 (2006.01), C07D 405/14 (2006.01), C07D 413/08 (2006.01)
Applicants: INCYTE CORPORATION [US/US]; Experimental Station, Building E336/225, Route 141 & Henry Clay Road, Wilmington, DE 19880 (US) (For All Designated States Except US).
LI, Yun-Long [CN/US]; (US) (For US Only).
ZHOU, Jincong [CN/US]; (US) (For US Only).
BURNS, David [US/US]; (US) (For US Only).
YAO, Wenqing [US/US]; (US) (For US Only)
Inventors: LI, Yun-Long; (US).
ZHOU, Jincong; (US).
BURNS, David; (US).
YAO, Wenqing; (US).
JALLURI, Ravi, Kumar; (US)
Agent: SIMKIN, Michele, M.; Foley & Lardner LLP, Washington Harbour, 3000 K Street N.W., Suite 500, Washington, DC 20007-5143 (US)
Priority Data:
60/512,016 17.10.2003 US
60/515,352 28.10.2003 US
60/586,646 12.07.2004 US
Title (EN) SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES
(FR) INHIBITEURS DE METALLOPROTEASES MATRICES A BASE D'HYDROXAMATES CYCLIQUES SUBSTITUES
Abstract: front page image
(EN)The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
(FR)La présente invention concerne des composés représentés par la formule (I), ses énantiomères, diastéréomères, certains de leurs mélanges racémiques, promédicaments, formes cristallines, formes non-cristallines, formes amorphes, solvates, métabolites, et sels pharmaceutiquement admis, les groupes substituants du noyau étant ceux définis dans la présente demande. Les composés représentés par la formule (I), qui sont des inhibiteurs de métalloprotéases tels que les métalloprotéases matrices et les sheddases, conviennent particulièrement au traitement d'affections telles que l'arthrite rhumatoïde, le psoriasis, les affections néoplasiques les allergies et celles des affections dans lesquelles l'inhibition des métalloprotéases matrices s'avère bénéfique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)