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1. (WO2005037812) FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/037812 International Application No.: PCT/GB2004/004392
Publication Date: 28.04.2005 International Filing Date: 15.10.2004
IPC:
C07D 307/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
34
having two or three double bonds between ring members or between ring members and non-ring members
56
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
68
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applicants:
CLARK, David, Edward [GB/GB]; GB (UsOnly)
HARRIS, Neil, Victor [GB/GB]; GB (UsOnly)
FENTON, Garry [GB/GB]; GB (UsOnly)
HYND, George [GB/GB]; GB (UsOnly)
STUTTLE, Keith, Alfred, James [GB/GB]; GB (UsOnly)
SUTTON, Jonathan, Mark [GB/GB]; GB (UsOnly)
OXFORD, Alexander, William [GB/GB]; GB (UsOnly)
DAVIS, Richard, Jon [GB/GB]; GB (UsOnly)
COLEMAN, Robert, Alexander [GB/GB]; GB (UsOnly)
CLARK, Kenneth, Lyle [GB/GB]; GB (UsOnly)
ASTERAND UK LIMITED [GB/GB]; 2 Orchard Road Royston Hertfordshire SG8 5HD, GB (AllExceptUS)
Inventors:
CLARK, David, Edward; GB
HARRIS, Neil, Victor; GB
FENTON, Garry; GB
HYND, George; GB
STUTTLE, Keith, Alfred, James; GB
SUTTON, Jonathan, Mark; GB
OXFORD, Alexander, William; GB
DAVIS, Richard, Jon; GB
COLEMAN, Robert, Alexander; GB
CLARK, Kenneth, Lyle; GB
Agent:
WATSON, Robert ; Mewburn Ellis LLP York House 23 Kingsway London Greater London WC2B 6HP, GB
Priority Data:
0324269.016.10.2003GB
60/512,20020.10.2003US
Title (EN) FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
(FR) DERIVES DE FURANE UTILISES COMME ANTAGONISTES DU RECEPTEUR EP4
Abstract:
(EN) A compound of formula: (I); or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m + n = 1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula: (II); (iii) a group of formula: (III); wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4 , where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
(FR) L'invention concerne un composé représenté par la formule: (I); ou un sel, un solvate et une forme chimiquement protégée de celui-ci, R2 ou R5 représentant: (i) H ou un groupe alkyle C1-4 éventuellement substitué, ou (ii) un aryle C5-7 éventuellement substitué; le R2 ou R5 restant représente l'autre groupe; m et n peuvent représenter 0 ou 1, et m + n = 1 ou 2, RN représente H ou alkyle C1-4 éventuellement substitué, R3 représente soit: (i) carboxy; soit (ii) un groupe représenté par la formule (II): (II); (iii) un groupe représenté par la formule (III): (III); dans lesquelles R représente alkyle C1-7 éventuellement substitué, aryle C5-20, ou NRN3RN4, dans cette dernière formule RN3 et RN4 sont choisis séparément dans alykle C1-4 éventuellement substitué, ou (iv) tétrazol-5-yl.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)