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1. (WO2005037779) NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS USED FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/037779    International Application No.:    PCT/EP2004/011645
Publication Date: 28.04.2005 International Filing Date: 15.10.2004
IPC:
A61K 31/55 (2006.01), C07D 405/12 (2006.01)
Applicants: IMTM GMBH [DE/DE]; Leipziger Strasse 44, 39120 Magdeburg (DE) (For All Designated States Except US).
KEYNEUROTEK AG [DE/DE]; Zenit Technologiepark, Leipziger Str. 44, 39120 Magbeburg (DE) (For All Designated States Except US).
ANSORGE, Siegfried [DE/DE]; (DE) (For US Only).
BANK, Ute [DE/DE]; (DE) (For US Only).
NORDHOFF, Karsten [DE/DE]; (DE) (For US Only).
TÄGER, Michael [DE/DE]; (DE) (For US Only).
STRIGGOW, Frank [DE/DE]; (DE) (For US Only)
Inventors: ANSORGE, Siegfried; (DE).
BANK, Ute; (DE).
NORDHOFF, Karsten; (DE).
TÄGER, Michael; (DE).
STRIGGOW, Frank; (DE)
Agent: KOEPE, Gerd, L.; Koepe & Partner, Robert-Koch-Str. 1, 80538 München (DE)
Priority Data:
103 48 022.6 15.10.2003 DE
Title (DE) NEUE DIPEPTIDYLPEPTIDASE IV-INHIBITOREN ZUR FUNKTIONELLEN BEEINFLUSSUNG UNTERSCHIEDLICHER ZELLEN UND ZUR BEHANDLUNG IMMUNOLOGISCHER, ENTZÜNDLICHER, NEURONALER UND ANDERER ERKRANKUNGEN
(EN) NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS USED FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES
(FR) NOUVEAUX INHIBITEURS DE DIPEPTIDYLPEPTIDASES IV DESTINES A INFLUENCER LE FONCTIONNEMENT DE DIVERSES CELLULES ET A TRAITER DES MALADIES IMMUNOLOGIQUES, INFLAMMATOIRES, NEURONALES ET AUTRES
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft Substanzen, die Gly-Pro-p-Nitroanilid spaltende Peptidasen spezifisch inhibieren, für die Verwendung in der Medizin. Weiter betrifft die Erfindung die Verwendung mindestens einer derartigen Substanz oder mindestens einer mindestens eine derartige Substanz enthaltenden pharmazeutischen oder kosmetischen Zusammensetzung zur Prophylaxe und Therapie von Erkrankungen, insbesondere zur Prophylaxe und Therapie von Erkrankungen mit überschiessender Immunantwort (Autoimmunerkrankungen, Allergien und Transplantatrejektionen), von anderen chronisch-entzündlichen Erkrankungen, neuronalen Erkrankungen und zerebralen Schädigungen, Hauterkrankungen (u. a. Akne und Schuppenflechte), Tumorerkrankungen und speziellen Virusinfektionen (u. a. SARS).
(EN)The invention relates to medicinally used substances which specifically inhibit peptidases splitting Gly-Pro-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmetic composition containing at least one such substance for preventing and treating diseases, particularly diseases with an overshooting immune response (autoimmune diseases, allergies, and transplant rejections), other chronic inflammatory diseases, neuronal diseases, brain damages, skin diseases (acne and psoriasis, among others), tumor diseases, and special viral infections (including SARS).
(FR)La présente invention concerne des substances inhibant spécifiquement des peptidases divisant gly-pro-p-nitroanilide, destinées à une utilisation médicale. L'invention concerne également l'utilisation d'une telle substance ou d'au moins une composition pharmaceutique ou cosmétique contenant au moins une telle substance, pour la prophylaxie et le traitement de maladies, notamment de maladies caractérisées par une réponse immunitaire excessive (maladies auto-immunes, allergies et rejets de greffes), d'autres maladies inflammatoires chroniques, de maladies neuronales et de traumatismes cérébraux, de maladies cutanées (par ex. l'acné et le psoriasis), de maladies tumorales et d'infections virales spécifiques (par ex. le SRAS).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)