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1. (WO2005037287) ORAL ADMINISTRATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)­ EN-2-YL)ALKYL]PHOSPHONIC ACID AND DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/037287    International Application No.:    PCT/US2004/034113
Publication Date: 28.04.2005 International Filing Date: 14.10.2004
IPC:
A61K 31/55 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
BENJAMIN, Eric, J. [US/US]; (US) (For US Only).
CLOUD, William, F. [US/US]; (US) (For US Only).
ASHRAF, Muhammad [PK/US]; (US) (For US Only).
ISLAM, Mohammed [US/US]; (US) (For US Only).
BRANDT, Michael, R. [US/US]; (US) (For US Only).
TREMBLAY, Gerald, F. [US/US]; (US) (For US Only)
Inventors: BENJAMIN, Eric, J.; (US).
CLOUD, William, F.; (US).
ASHRAF, Muhammad; (US).
ISLAM, Mohammed; (US).
BRANDT, Michael, R.; (US).
TREMBLAY, Gerald, F.; (US)
Agent: LUCCI, Joseph; Woodcock Washburn LLP, One Liberty Place, 46th Floor, Philadelphia, PA 19103 (US)
Priority Data:
60/511,560 15.10.2003 US
10/961,871 08.10.2004 US
Title (EN) ORAL ADMINISTRATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)­ EN-2-YL)ALKYL]PHOSPHONIC ACID AND DERIVATIVES
(FR) ADMINISTRATION ORALE D'ACIDE PHOSPHONIQUE [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)- EN-2-YL)ALKYL] ET DE DERIVES DE CELUI-CI
Abstract: front page image
(EN)Solid, pharmaceutical dosage forms of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.0]non­1(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof are disclosed. In addition, methods of use are disclosed for the treatment, inter alia, of cerebral vascular disorders, anxiety disorders; mood disorders; schizophrenia; schizophreniform disorder; schizoaffective disorder; cognitive impairment; chronic neurodegenerative disorders; inflammatory diseases; fibromyalgia; complications from herpes zoster; prevention of tolerance to opiate analgesia; withdrawal symptoms from addictive drugs; and pain.
(FR)La présente invention concerne des formes posologiques pharmaceutiques solides d'acide phosphonique [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] et de dérivés de celui-ci. En outre, l'invention concerne des méthodes d'utilisation de ces formes posologiques pharmaceutiques pour le traitement, entre autres, de troubles vasculaires cérébraux, de troubles de l'anxiété, de troubles de l'humeur, de la schizophrénie, de troubles schizophréniformes, de troubles schizo-affectifs, de troubles cognitifs, de troubles neurodégénératifs chroniques, de maladies inflammatoires, d'une fibromyalgie ; de complications suite à un zona. Ces compositions permettent également de prévenir la tolérance à une analgésie opiacée, aux symptômes de sevrage de drogues induisant une pharmacodépendance, et à la douleur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)