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1. (WO2005037257) NOVEL ALANYL-AMINO PEPTIDASE INHIBITORS FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/037257 International Application No.: PCT/EP2004/011643
Publication Date: 28.04.2005 International Filing Date: 15.10.2004
IPC:
A61K 31/00 (2006.01) ,A61K 31/4015 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4015
having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
Applicants: ANSORGE, Siegfried[DE/DE]; DE (UsOnly)
BANK, Ute[DE/DE]; DE (UsOnly)
NORDHOFF, Karsten[DE/DE]; DE (UsOnly)
TÄGER, Michael[DE/DE]; DE (UsOnly)
STRIGGOW, Frank[DE/DE]; DE (UsOnly)
IMTM GMBH[DE/DE]; Leipziger Strasse 44 39120 Magdeburg, DE (AllExceptUS)
KEYNEUROTEK AG[DE/DE]; ZENIT Technologiepark Leipziger Str. 44 39120 Magdeburg, DE (AllExceptUS)
Inventors: ANSORGE, Siegfried; DE
BANK, Ute; DE
NORDHOFF, Karsten; DE
TÄGER, Michael; DE
STRIGGOW, Frank; DE
Agent: KOEPE, Gerd, L.; Koepe & Partner Robert-Koch-Str. 1 80538 München, DE
Priority Data:
103 48 023.415.10.2003DE
Title (EN) NOVEL ALANYL-AMINO PEPTIDASE INHIBITORS FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES
(FR) NOUVEAUX INHIBITEURS D'ALANYL-AMINOPEPTIDASES DESTINES A EXERCER UNE INFLUENCE FONCTIONNELLE SUR DIVERSES CELLULES ET A CONSTITUER UN TRAITEMENT IMMUNOLOGIQUE DE MALADIES INFLAMMATOIRES, NEURONALES ET AUTRES
(DE) NEUE ALANYL-AMINOPEPTIDASEN-INHIBITOREN ZUR FUNKTIONELLEN BEEINFLUSSUNG UNTERSCHIEDLICHER ZELLEN UND ZUR BEHANDLUNG IMMUNOLOGISCHER, ENTZÜNDLICHER, NEURONALER UND ANDERER ERKRANKUNGEN
Abstract:
(EN) The invention relates to medicinally used substances which specifically inhibit peptidases splitting ala-p-nitroanilide. The invention further relates to the use of at least one such substance or at least one pharmaceutical or cosmetic composition containing such a substance for preventing and treating diseases, especially diseases with an overshooting immune response (autoimmune diseases, allergies, and transplant rejections), other chronic inflammatory diseases, neuronal diseases, brain damages, skin diseases (acne and psoriasis, among others), tumor diseases, and special viral infections (including SARS).
(FR) La présente invention concerne des substances inhibant spécifiquement des peptidases divisant ala-p-nitroanilide, destinées à une utilisation en médecine. L'invention concerne également l'utilisation d'au moins une telle substance ou d'au moins une composition pharmaceutique ou cosmétique contenant au moins une telle substance, dans la prophylaxie et la thérapie de maladies, notamment de maladies caractérisées par une réponse immunitaire excessive (maladies auto-immunes, allergies et rejets de greffes), d'autres maladies inflammatoires chroniques, de maladies neuronales, de traumatismes cérébraux, de maladies dermatologiques (par ex. l'acné et le psoriasis), de maladies tumorales et d'infections virales spécifiques (par ex. le SRAS).
(DE) Die vorliegende Erfindung betrifft Substanzen, die Ala-p-Nitroanilid spaltende Peptidasen spezifisch inhibieren, für die Verwendung in der Medizin. Weiter betrifft die Erfindung die Verwendung mindestens einer derartigen Substanz oder mindestens einer mindestens eine derartige Substanz enthaltenden pharmazeutischen oder kosmetischen Zusammensetzung zur Prophylaxe und Therapie von Erkrankungen, insbesondere zur Prophylaxe und Therapie von Erkrankungen mit überschiessender Immunantwort (Autoimmunerkrankungen, Allergien und Transplantatrejektionen), von anderen chronisch-entzündlichen Erkrankungen, neuronalen Erkrankungen und zerebralen Schädigungen, Hauterkrankungen (u. a. Akne und Schuppenflechte), Tumorerkrankungen und speziellen Virusinfektionen (u. a. SARS).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)