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1. (WO2005036132) METHODS AND DEVICES FOR CONCENTRATION AND PURIFICATION OF ANALYTES FOR CHEMICAL ANALYSIS INCLUDING MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) MASS SPECTROMETRY (MS)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/036132    International Application No.:    PCT/US2004/033471
Publication Date: 21.04.2005 International Filing Date: 12.10.2004
IPC:
H01J 49/04 (2006.01)
Applicants: PROTEIN DISCOVERY, INC. [US/US]; 11020 Solway School Road, Suite 101, Knoxville, TN 37931 (US) (For All Designated States Except US).
HAFEMAN, Dean, G. [US/US]; (US) (For US Only).
DILL, Kilian [US/US]; (US) (For US Only).
HARKINS, James, B., IV [US/US]; (US) (For US Only).
CAPRIOLI, Richard, M. [US/US]; (US) (For US Only).
NORRIS, Jeremy [US/US]; (US) (For US Only).
LEWIS, Nathan, S. [US/US]; (US) (For US Only).
KUBAN, Daniel [US/US]; (US) (For US Only).
WITKNOWSKI, Charles, E., II [US/US]; (US) (For US Only)
Inventors: HAFEMAN, Dean, G.; (US).
DILL, Kilian; (US).
HARKINS, James, B., IV; (US).
CAPRIOLI, Richard, M.; (US).
NORRIS, Jeremy; (US).
LEWIS, Nathan, S.; (US).
KUBAN, Daniel; (US).
WITKNOWSKI, Charles, E., II; (US)
Agent: HUGHES, Blair, A.; McDonnell Boehnen Hulbert & Berghoff LLP, Suite 3100, 300 South Wacker Drive, Chicago, IL 60606 (US)
Priority Data:
60/511,615 10.10.2003 US
60/581,843 22.06.2004 US
60/586,099 07.07.2004 US
  12.10.2004 US (Considered void 25.01.2005)
Title (EN) METHODS AND DEVICES FOR CONCENTRATION AND PURIFICATION OF ANALYTES FOR CHEMICAL ANALYSIS INCLUDING MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) MASS SPECTROMETRY (MS)
(FR) PROCEDES ET DISPOSITIFS POUR CONCENTRATION ET EPURATION D'ANALYTES EN VUE D'UNE ANALYSE CHIMIQUE INCLUANT UNE SPECTROMETRIE DE MASSE (MS) A DESORPTION-IONISATION PAR IMPACT LASER ASSISTEE PAR MATRICE (MALDI)
Abstract: front page image
(EN)Analytical methods and devices are disclosed for separating low abundance analytes by electrophoretically driving the analytes through a sieving matrix to first remove high molecular weight species. Subsequently the remaining low abundance analytes are electrophoretically focused onto a capture membrane where the analytes become bound within a small capture site. After this step the capture membrane may be allowed to dry and then attached to a conductive MALDI sample plate.
(FR)L'invention concerne des procédés analytiques et des dispositifs destinés à séparer des analytes peu abondants et permettant d'entraîner les analytes par voie électrophorétique à travers une matrice de tamisage en vue d'enlever d'abord les espèces de poids moléculaire élevé. Ensuite, les analytes peu abondants restants sont concentrés par voie électrophorétique sur une membrane de capture, les analytes se liant à l'intérieur d'un site de capture restreint. Après cette étape, la membrane de capture peut sécher et être fixée à une plaque d'échantillon MALDI conductrice.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)