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1. (WO2005035753) DOUBLE SPECIFIC ANTIBODIES SUBSTITUTING FOR FUNCTIONAL PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/035753    International Application No.:    PCT/JP2003/013062
Publication Date: 21.04.2005 International Filing Date: 10.10.2003
Chapter 2 Demand Filed:    22.04.2005    
IPC:
C07K 16/28 (2006.01), C07K 16/36 (2006.01)
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 115-8543 (JP) (For All Designated States Except US).
HATTORI, Kunihiro [JP/JP]; (JP) (For US Only).
KOJIMA, Tetsuo [JP/JP]; (JP) (For US Only).
MIYAZAKI, Taro [JP/JP]; (JP) (For US Only).
SOEDA, Tetsuhiro [JP/JP]; (JP) (For US Only).
SENOO, Chiaki [JP/JP]; (JP) (For US Only).
NATORI, Osamu [JP/JP]; (JP) (For US Only).
KASUTANI, Keiko [JP/JP]; (JP) (For US Only).
ISHII, Shinya [JP/JP]; (JP) (For US Only)
Inventors: HATTORI, Kunihiro; (JP).
KOJIMA, Tetsuo; (JP).
MIYAZAKI, Taro; (JP).
SOEDA, Tetsuhiro; (JP).
SENOO, Chiaki; (JP).
NATORI, Osamu; (JP).
KASUTANI, Keiko; (JP).
ISHII, Shinya; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 300-0847 (JP)
Priority Data:
Title (EN) DOUBLE SPECIFIC ANTIBODIES SUBSTITUTING FOR FUNCTIONAL PROTEIN
(FR) ANTICORPS A DOUBLE SPECIFICITE REMPLAÇANT UNE PROTEINE FONCTIONNELLE
(JA) 機能蛋白質を代替する二重特異性抗体
Abstract: front page image
(EN)A bispecific antibody substituting for a ligand for a I type interferon receptor comprising two types of molecules having AR1 and AR2 chains is successfully isolated. Further, a bispecific antibody binding to both of blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and substituting for the function of blood coagulation factor VIII/activated blood coagulation factor VIII enhancing an enzyme reaction is successfully constructed.
(FR)L'invention concerne un anticorps bispécifique qui se substitue à un ligand d'un récepteur d'interféron du type I comprenant deux types de molécules pourvues de chaînes AR1 et AR2. L'invention concerne aussi un anticorps bispécifique se liant à la fois au facteur IX de la coagulation sanguine/ facteur IX activé et au facteur X de la coagulation sanguine, et qui remplace la fonction du facteur VIII de la coagulation sanguine/facteur VIII activé, renforçant ainsi une réaction enzymatique.
(JA)AR1鎖,AR2鎖の二種の分子から成るI型インターフェロン受容体に対するリガンド機能代替二種特異性抗体の分離に成功した。また、血液凝固第IX因子/活性化血液凝固第IX因子及び血液凝固第X因子の双方に結合し、酵素反応を増強させる血液凝固第VIII因子/活性化血液凝固第VIII因子の作用を代替する二種特異性抗体を作製することに成功した。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)