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Machine translation
1. (WO2005035722) VARIANT POLYPEPTIDES CONTAINING PLEKSTRIN HOMOLOGY DOMAINS AND USES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/035722    International Application No.:    PCT/US2004/033017
Publication Date: 21.04.2005 International Filing Date: 07.10.2004
IPC:
C07K 14/00 (2006.01)
Applicants: UNIVERSITY OF MASSACHUSETTS [US/US]; One Beacon Street, 26th Floor, Boston, MA 02108 (US) (For All Designated States Except US).
LAMBRIGHT, David, G. [--/US]; (US) (For US Only).
CZECH, Michael, P. [US/US]; (US) (For US Only).
CRONIN, Thomas; (For US Only)
Inventors: LAMBRIGHT, David, G.; (US).
CZECH, Michael, P.; (US).
CRONIN, Thomas;
Agent: MILASINCIC, Debra, J.; Lahive & Cockfield, LLP, 28 State Street, Boston, MA 02109 (US)
Priority Data:
60/509,777 07.10.2003 US
Title (EN) VARIANT POLYPEPTIDES CONTAINING PLEKSTRIN HOMOLOGY DOMAINS AND USES THEREFOR
(FR) POLYPEPTIDES VARIANTS CONTENANT DES DOMAINES D'HOMOLOGIE A LA PLECKSTRINE, ET LEURS UTILISATIONS
Abstract: front page image
(EN)The instant invention provides polypeptides comprising variant pleckstrin homology (PH) domains. The invention provides polypeptides having increased or decreased binding specificity for a phosphatidylinositide molecule to which the PH domain naturally binds. Further, the invention provides polypeptides having increased binding specificity for a phosphatidylinositide molecule to which the PH domain naturally does not bind.
(FR)La présente invention se rapporte à des polypeptides contenant des domaines d'homologies à la pleckstrine (PH) variants. L'invention a trait à des polypeptides présentant une spécificité de liaison augmentée ou diminuée pour une molécule de phosphatidylinositide à laquelle le domaine PH se lie naturellement. De plus, l'invention concerne des polypeptides présentant une spécificité de liaison augmentée pour une molécule de phosphatidylinositide à laquelle le domaine PH ne se lie pas naturellement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)