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Pub. No.:    WO/2005/035553    International Application No.:    PCT/DK2004/000685
Publication Date: 21.04.2005 International Filing Date: 08.10.2004
C07C 237/20 (2006.01), C07C 237/22 (2006.01), C07C 323/60 (2006.01), C07K 1/00 (2006.01), C07K 14/61 (2006.01), C12P 21/02 (2006.01), A61K 38/00 (2006.01), C12P 21/00 (2006.01)
Applicants: NOVO NORDISK A/S [DK/DK]; Novo Allé, DK-2880 Bagsværd (DK) (For All Designated States Except US).
ZUNDEL, Magali A. [FR/DK]; (DK) (For US Only).
PESCHKE, Bernd [DE/DK]; (DK) (For US Only).
DÖRWALD, Florencio, Zaragoza [DE/DK]; (DK) (For US Only).
FIIL, Niels, Peter [DK/DK]; (DK) (For US Only).
JOHANSEN, Nils, Langeland [DK/DK]; (DK) (For US Only).
STENNICKE, Henning, Ralf [DK/DK]; (DK) (For US Only)
Inventors: ZUNDEL, Magali A.; (DK).
PESCHKE, Bernd; (DK).
DÖRWALD, Florencio, Zaragoza; (DK).
FIIL, Niels, Peter; (DK).
JOHANSEN, Nils, Langeland; (DK).
STENNICKE, Henning, Ralf; (DK)
NOVO NORDISK A/S; Corporate Patents, Novo Allé, DK-2880 Bagsværd (DK)
Priority Data:
PA 2003 01496 10.10.2003 DK
60/510,892 14.10.2003 US
Abstract: front page image
(EN)Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said second compound comprises a functional group which selectively reacts with the incorporated functional group.
(FR)Procédés de conjugaison sélective de peptides, comprenant une incorporation enzymatique d'un groupe fonctionnel à l'extrémité terminale C d'un peptide, suivie d'une réaction avec un second composé comprenant la fraction à conjuguer du peptide, ledit second composé comprenant un groupe fonctionnel qui réagit sélectivement avec le groupe fonctionnel incorporé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)