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1. (WO2005035549) AMIPHIPHYLIC PEPTIDE-PNA CONJUGATES FOR THE DELIVERY OF PNA THROUGH THE BLOOD BRAIN BARRIER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/035549    International Application No.:    PCT/IL2004/000938
Publication Date: 21.04.2005 International Filing Date: 13.10.2004
IPC:
C07H 21/04 (2006.01), C12Q 1/68 (2006.01), A61K 31/70 (2006.01)
Applicants: KERNEL BIOPHARMA INC. [IL/IL]; c/o Itschak Lamensdorf, Nahal Bezek 9/3, 71700 Modiin (IL) (For All Designated States Except US).
LAMENSDORF, Itschak [IL/IL]; (IL) (For US Only).
KATZHENDLER, Jehoshua [IL/IL]; (IL) (For US Only)
Inventors: LAMENSDORF, Itschak; (IL).
KATZHENDLER, Jehoshua; (IL)
Agent: EITAN, PEARL, LATZER & COHEN-ZEDEK; 7 Shenkar Street, 46725 Herzlia (IL)
Priority Data:
60/510,139 14.10.2003 US
Title (EN) AMIPHIPHYLIC PEPTIDE-PNA CONJUGATES FOR THE DELIVERY OF PNA THROUGH THE BLOOD BRAIN BARRIER
(FR) CONJUGUES DE PEPTIDE PNA AMIPHIPHYLIQUE DESTINES A ADMINISTRER DU PNA A TRAVERS LA BARRIERE HEMATO-ENCEPHALIQUE
Abstract: front page image
(EN)The invention provides molecules comprising a nucleic acid, a hydrophobic moiety and a positively charge moiety, useful in the delivery of a nucleic acid sequence across a cellular membrane. The invention further relates to the use of these molecules for the delivery of a nucleic acid sequence to the brain across the blood brain barrier for diagnostic and therapeutic applications.
(FR)L'invention concerne des molécules comprenant un acide nucléique, une fraction hydrophobe et une fraction positivement chargée, utile dans l'administration d'une séquence d'acide nucléique à travers une membrane cellulaire. L'invention concerne également l'utilisation de ces molécules afin d'administrer une séquence d'acide nucléique au cerveau à travers la barrière hémato-encéphalique dans des applications de diagnostic et de traitement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)