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Machine translation
1. (WO2005035525) 2-AMIDO-4-ARYLOXY-1-CARBONYLPYRROLIDINE DERIVATIVES AS INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/035525 International Application No.: PCT/US2004/029093
Publication Date: 21.04.2005 International Filing Date: 07.09.2004
IPC:
A61K 31/4178 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/497 (2006.01) ,A61K 31/501 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/517 (2006.01) ,A61K 38/00 (2006.01) ,A61K 45/06 (2006.01) ,C07D 401/12 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,C07K 5/02 (2006.01) ,C07K 5/10 (2006.01)
Applicants: PERNI, Robert, B.[US/US]; US (UsOnly)
COURT, John, J.[US/US]; US (UsOnly)
BRITT, Shawn, D.[US/US]; US (UsOnly)
PITLIK, Janos[HU/US]; US (UsOnly)
VAN DRIE, John, H.[US/US]; US (UsOnly)
VERTEX PHARMACEUTICALS INCORPORATED[US/US]; 130 Waverly Street Cambridge, MA 02139-4242, US (AllExceptUS)
Inventors: PERNI, Robert, B.; US
COURT, John, J.; US
BRITT, Shawn, D.; US
PITLIK, Janos; US
VAN DRIE, John, H.; US
Agent: HALEY, James, F., Jr.; Fish & Neave IP Group of Ropes & Gray LLP 1251 Avenue of the Americas New York, NY 10020, US
Priority Data:
60/500,67005.09.2003US
Title (EN) 2-AMIDO-4-ARYLOXY-1-CARBONYLPYRROLIDINE DERIVATIVES AS INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE
(FR) INHIBITEURS DES SERINES PROTEASES, EN PARTICULIER DE LA PROTEASE NS3-NS4A DU VIRUS DE L'HEPATITE C (VHC)
Abstract:
(EN) The present invention relates to compounds of formula I-A and I-B that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
(FR) Cette invention concerne des composés inhibant l'activité des sérines protéases, plus particulièrement, l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Lesdits composés agissent en intervenant dans le cycle de vie du virus de l'hépatite C, et sont utilisés comme agents antiviraux. Cette invention concerne également des composition comprenant ces composés, soit pour une utilisation ex vivo, soit pour une administration à un patient souffrant d'une infection à VHC. Cet invention concerne également des méthodes permettant de traiter une infection à VHC chez un patient, par administration d'une composition comprenant le composé décrit dans l'invention. En outre, on décrit des procédés permettant d'élaborer ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)