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Machine translation
1. (WO2005035496) PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/035496 International Application No.: PCT/US2004/032086
Publication Date: 21.04.2005 International Filing Date: 01.10.2004
Chapter 2 Demand Filed: 14.06.2005
IPC:
C07D 209/08 (2006.01) ,C07D 209/86 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/12 (2006.01)
Applicants: WEIBERTH, Franz[US/US]; US (UsOnly)
LEE, George, E.[US/US]; US (UsOnly)
HANNA, Reda, G.[US/US]; US (UsOnly)
DUBBERKE, Silke[DE/DE]; DE (UsOnly)
UTZ, Roland[DE/IT]; IT (UsOnly)
MUELLER-LEHAR, Jurgen[DE/DE]; DE (UsOnly)
AVENTIS PHARMACEUTICALS INC.[US/US]; 300 Somerset Corporate Boulevard Bridgewater, NJ 08807-2854, US (AllExceptUS)
Inventors: WEIBERTH, Franz; US
LEE, George, E.; US
HANNA, Reda, G.; US
DUBBERKE, Silke; DE
UTZ, Roland; IT
MUELLER-LEHAR, Jurgen; DE
Agent: GUPTA, Balaram ; Aventis Pharmaceuticals Inc. Route 202-206 P.O. Box 6800 Bridgewater, NJ 08807-0800, US
Priority Data:
60/508,33503.10.2003US
Title (EN) PROCESS FOR THE PREPARATION OF N-AMINO SUBSTITUTED HETEROCYCLIC COMPOUNDS
(FR) PROCEDE DE PREPARATION DE COMPOSES HETEROCYCLIQUES A SUBSTITUTION N-AMINO
Abstract: front page image
(EN) An improved process for the preparation of N-amino nitrogen heterocyclic compounds is disclosed and claimed. In an ambodiment of this invention, a compound of the formula (VI) is prepared starting from the corresponding indole derivative by way of N-amination and subsequently forming an hydrazone by the reaction with a keto compound in a single step. Further reduction of the hydrazone and subsequent coupling with a pyridine compound affords the compound of formula VI or a suitable salt thereof.
(FR) L'invention décrit un procédé amélioré de préparation de composés hétérocycliques d'azote N-amino. Dans un mode de réalisation de l'invention, un composé de formule (VI) est obtenu à partir du dérivé d'indole correspondant par N-amination puis par formation d'un hydrazone par réaction avec un composé cétone en une seule étape. La réduction de l'hydrazone et le couplage subséquent avec un composé pyridine permettent d'obtenir le composé de formule VI ou un sel approprié correspondant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)