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Machine translation
1. (WO2005034919) METHOD OF PRODUCING DOSAGE UNITS OF A SOLID DRUG FORM CONTAINING WARFARIN SODIUM SALT AS ACTIVE COMPONENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/034919    International Application No.:    PCT/CZ2004/000067
Publication Date: 21.04.2005 International Filing Date: 14.10.2004
Chapter 2 Demand Filed:    09.07.2005    
IPC:
A61K 9/16 (2006.01), A61K 9/20 (2006.01), A61K 31/00 (2006.01)
Applicants: PLIVA-LACHEMA a.s. [CZ/CZ]; Karasek 1, 621 33 Brno (CZ) (For All Designated States Except US).
FRANC, Ales [CZ/CZ]; (CZ) (For US Only).
ZALUDEK, Borek [CZ/CZ]; (CZ) (For US Only).
GONEC, Roman [CZ/CZ]; (CZ) (For US Only).
MALECEK, Miroslav [CZ/CZ]; (CZ) (For US Only).
TKADLECKOVA, Hana [CZ/CZ]; (CZ) (For US Only).
PETROVICOVA, Anna [CZ/CZ]; (CZ) (For US Only)
Inventors: FRANC, Ales; (CZ).
ZALUDEK, Borek; (CZ).
GONEC, Roman; (CZ).
MALECEK, Miroslav; (CZ).
TKADLECKOVA, Hana; (CZ).
PETROVICOVA, Anna; (CZ)
Agent: KUBAT, Jan; Traplova Hakr Kubat, Law and Patent Offices, Po Box 38, Pristavni 24, 170 00 Praha 7 (CZ)
Priority Data:
PV 2854-03 17.10.2003 CZ
Title (EN) METHOD OF PRODUCING DOSAGE UNITS OF A SOLID DRUG FORM CONTAINING WARFARIN SODIUM SALT AS ACTIVE COMPONENT
(FR) PROCEDE DE PRODUCTION DE DOSES POSOLOGIQUES SOLIDES D'UN MEDICAMENT A BASE DE SEL DE WARFARINE SODIQUE
Abstract: front page image
(EN)The invention relates to a method of producing dosage units of a solid drug form containing as the active substance warfarin sodium salt in an amount of 1 to 10 mg and having high degree of content uniformity satisfying the Bergum criterion, characterized in that an aqueous solution of warfarin sodium salt and /or its clathrate which optionally contains in the dissolved state one of the pharmaceutically acceptable excipients co-forming the solid drug form to be prepared but not all the pharmaceutically acceptable excipients co-forming the solid drug form to be prepared, is brought into contact with solid particles of at least one pharmaceutically acceptable excipient co-forming the solid drug form to be prepared, whereupon optionally the particles are dried and optionally mixed with a required amount of solid particles of the remaining pharmaceutically acceptable excipients co-forming the solid drug form to be prepared, and the thus-obtained particulate mixture is formulated into dosage units of the solid drug form.
(FR)La présente invention concerne un procédé de production de doses posologiques solides d'un médicament à base de sel de warfarine sodique dosée de 1 à 10 mg avec un contenu hautement homogène (critères de Bergum). En l'occurrence, on prend une solution aqueuse de sel de warfarine sodique et/ou son clathrate, qui est éventuellement capable de contenir en solution l'un des excipients pharmaceutiquement admis, mais pas tous, concourant à la formation de la forme solide demandée, et on met cette solution en contact avec des particules solides de l'excipient considéré. Par la suite, on peut faire sécher les particules et éventuellement les mélanger avec une quantité requise de particules solides d'autres excipients de confection de médicaments solides. Il ne reste plus qu'à formuler le mélange particulaire ainsi obtenu en unité de dose posologique pour former le médicament solide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)