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1. (WO2005034733) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/034733 International Application No.: PCT/US2004/033176
Publication Date: 21.04.2005 International Filing Date: 08.10.2004
IPC:
A61K 38/00 (2006.01) ,A61K 39/395 (2006.01) ,C07H 21/04 (2006.01) ,C07K 14/00 (2006.01) ,C07K 16/00 (2006.01) ,C12N 15/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants: MESSMER, Bradley, T.[US/US]; US (UsOnly)
CHIORAZZI, Nicholas[IT/US]; US (UsOnly)
ALBESIANO, Emilia[IT/US]; US (UsOnly)
NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE[US/US]; 350 Community Drive Manhasset, NY 11030, US (AllExceptUS)
Inventors: MESSMER, Bradley, T.; US
CHIORAZZI, Nicholas; US
ALBESIANO, Emilia; US
Agent: ARNOLD, Craig, J. ; Amster, Rothstein & Ebenstein LLP 90 Park Avenue New York, NY 10016, US
Priority Data:
60/509,47308.10.2003US
Title (EN) METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA
(FR) TECHNIQUES ET COMPOSITIONS POUR LE DIAGNOSTIC ET LE TRAITEMENT DE LA LEUCEMIE LYMPHOCYTAIRE CHRONIQUE DES CELLULES BETA
Abstract:
(EN) Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype­ specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL.
(FR) La présente invention concerne des préparations isolées et purifiées d'une combinaison de chaînes d'anticorps à chaîne légère et de chaînes d'anticorps à chaîne lourde, les gènes d'anticorps de chaîne légère et de chaîne lourde étant les mêmes entre plus d'un patient atteint de leucémie lymphocytaire chronique de cellules bêta (B-CLL). Cette invention concerne aussi des vecteurs comprenant ces gènes et des cellules comprenant ces vecteurs, tels que sont des anticorps isolés et purifiés codés par ces gènes d'anticorps. Cette invention concerne aussi des anticorps anti-idiotype, des peptides et des aptamères qui se lient aux régions de liaison à l'antigène d'un anticorps codé par les gènes d'anticorps, tels que des molécules multimères comprenant des sites de liaison multiples qui se lient à des régions de liaison à l'antigène d'un anticorps codé par ces gènes d'anticorps. Cette invention concerne aussi des techniques permettant de déterminer si un patient atteint de leucémie lymphocytaire chronique de cellule bêta (B-CLL) présente une forme de B-CLL qui est susceptible de recevoir un traitement destiné à éliminer des cellules B-CLL porteuses de récepteur de cellule bêta spécifique d'idiotype, tels que les techniques qui suivent la progression du traitement de B-CLL chez ce patient. Par ailleurs, cette invention concerne des techniques de traitement d'un patient atteint de B-CLL, tels que des techniques d'identification d'agents thérapeutiques pour la B-CLL.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)