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Machine translation
1. (WO2005033330) FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/033330    International Application No.:    PCT/US2004/032253
Publication Date: 14.04.2005 International Filing Date: 30.09.2004
IPC:
C07D 405/12 (2006.01), C09B 11/24 (2006.01), G01N 33/542 (2006.01), G01N 33/573 (2006.01), G01N 33/58 (2006.01)
Applicants: BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. [US/US]; 900 Ridgebury Rd., P.O. Box 368, Ridgefield, CT 06877-0368 (US) (For All Designated States Except US).
PROKOPOWICZ, Anthony, S. [US/US]; (US) (For US Only).
BROWN, Martha, Priscilla [US/US]; (US) (For US Only).
JONES, Jessi, Wildeson [US/US]; (US) (For US Only).
JAKES, Scott [US/US]; (US) (For US Only).
LABADIA, Mark, E. [US/US]; (US) (For US Only)
Inventors: PROKOPOWICZ, Anthony, S.; (US).
BROWN, Martha, Priscilla; (US).
JONES, Jessi, Wildeson; (US).
JAKES, Scott; (US).
LABADIA, Mark, E.; (US)
Agent: RAYMOND, Robert, P.; 900 Ridgebury Rd., P.O. Box 368, Boehringer Ingelheim Corporation, Ridgefield, CT 06877-0368 (US)
Priority Data:
60/508,539 03.10.2003 US
Title (EN) FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY
(FR) SONDES FLUORESCENTES POUR TEST DE LIAISON D'INHIBITEUR DE PROTEINE KINASE
Abstract: front page image
(EN)The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound is derived based on the Kd of the probe for the kinase and the dose response of the inhibitor agent. The invention also provides novel active site probes suitable for use with the screening method.
(FR)L'invention concerne des procédés relatifs à un format de test d'analyse pouvant être appliqué à une large gamme de membres de la famille des gènes de protéine kinase. On utilise une série de sondes de site actif marquées, décrites dans l'invention, pouvant être déplacées par un agent inhibiteur. Le Kd pour le composé inhibiteur est dérivé sur la base du Kd de la sonde pour la kinase et de la dose-réponse de l'agent inhibiteur. L'invention concerne également des sondes de site actif se prêtant à une utilisation dans le cadre du procédé considéré.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)