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1. (WO2005033294) METHODS FOR MAINTAINING HEPATOCYTES IN CULTURE AND FOR DIFFERENTIATING EMBRYONIC STEM CELLS ALONG A HEPATOCYTE LINEAGE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/033294 International Application No.: PCT/US2004/032701
Publication Date: 14.04.2005 International Filing Date: 30.09.2004
IPC:
C12N 5/00 (2006.01)
Applicants: ZERN, Mark, A.[US/US]; US (UsOnly)
SHIRAHASHI, Hitoshi[JP/JP]; JP (UsOnly)
REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; University of California Office of Technology Transfer 1111 Franklin Street, 5th Floor Oakland, CA 94607-5200, US (AllExceptUS)
Inventors: ZERN, Mark, A.; US
SHIRAHASHI, Hitoshi; JP
Agent: HYMAN, Laurence, J. ; Townsend and Townsend and Crew LLP 2 Embarcadero Center, 8th Floor San Francisco, CA 94111, US
Priority Data:
60/507,78630.09.2003US
Title (EN) METHODS FOR MAINTAINING HEPATOCYTES IN CULTURE AND FOR DIFFERENTIATING EMBRYONIC STEM CELLS ALONG A HEPATOCYTE LINEAGE
(FR) METHODES PERMETTANT DE MAINTENIR DES HEPATOCYTES EN CULTURE ET DE DIFFERENCIER DES CELLULES SOUCHES EMBRYONNAIRES DANS UNE LIGNEE HEPATOCYTE
Abstract: front page image
(EN) The invention provides methods and media for culturing embryonic stem (ES) cells, such as human ES cells, and directing them along the hepatic lineage. It further provides methods for maintaining hepatocytes in culture for extended periods. The invention further provides cells cultured by the methods of the invention. Additionally, the invention provides methods of transducing cells with marker proteins that will be expressed only in hepatocyte-like cells and selecting for cells expressing the marker protein.
(FR) L'invention concerne des méthodes et des milieux permettant de cultiver des cellules souches embryonnaires, notamment humaines, et des les diriger sur une lignée hépatique. L'invention concerne également des méthodes permettant de maintenir des hépatocytes en culture pendant des périodes prolongées. Elle concerne en outre des cellules cultivées selon les méthodes de l'invention. Enfin, l'invention porte sur des méthodes de transduction de cellules avec des protéines de marquage qui s'exprimeront uniquement dans des cellules de type hépatocyte et de sélection de cellules exprimant la protéine de marquage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)