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1. (WO2005033140) HIGHLY PURE BLOOD COAGULATION FACTOR IX PREPARATION AND METHOD OF PURIFYING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/033140 International Application No.: PCT/JP2004/013905
Publication Date: 14.04.2005 International Filing Date: 24.09.2004
Chapter 2 Demand Filed: 29.07.2005
IPC:
A61K 38/48 (2006.01) ,C12N 9/64 (2006.01)
Applicants: SHIMODA, Junichi[JP/JP]; JP (UsOnly)
YANO, Hisashi[JP/JP]; JP (UsOnly)
MIYAGAWA, Minako[JP/JP]; JP (UsOnly)
HIGASHI, Mai[JP/JP]; JP (UsOnly)
OGATA, Yoichi[JP/JP]; JP (UsOnly)
HAMAMOTO, Takayoshi[JP/JP]; JP (UsOnly)
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE[JP/JP]; 6-1, Okubo 1-chome, Kumamoto-shi, Kumamoto 8608568, JP (AllExceptUS)
Inventors: SHIMODA, Junichi; JP
YANO, Hisashi; JP
MIYAGAWA, Minako; JP
HIGASHI, Mai; JP
OGATA, Yoichi; JP
HAMAMOTO, Takayoshi; JP
Agent: KAWAMIYA, Osamu; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001, JP
Priority Data:
2003-33920030.09.2003JP
Title (EN) HIGHLY PURE BLOOD COAGULATION FACTOR IX PREPARATION AND METHOD OF PURIFYING THE SAME
(FR) PREPARATION DE FACTEUR IX DE COAGULATION SANGUINE HAUTEMENT PURIFIEE ET PROCEDE DE PURIFICATION ASSOCIE
(JA) 高純度血液凝固IX因子調製物およびその精製方法
Abstract:
(EN) A method of purifying blood coagulation factor IX characterized by comprising eliminating a blood coagulation factor IX activator from a fraction containing blood coagulation factor IX and thus inhibiting the formation of activated blood coagulation factor IX; and a blood coagulation factor IX preparation obtained by this method which contains little FIXa and has a high safety. The blood coagulation factor IX activator as described above is mannose-binding lectin-associated serine protease-1 (MASP-1). It is preferable to eliminate the blood coagulation factor IX activator by hydrophobic chromatography.
(FR) L'invention concerne un procédé de purification du facteur IX de coagulation sanguine caractérisé en ce qu'il consiste à éliminer un activateur de facteur IX de coagulation sanguine d'une fraction contenant un facteur IX de coagulation sanguine et ainsi à inhiber la formation de facteur IX de coagulation sanguine activé. L'invention concerne également une préparation de facteur IX de coagulation sanguine obtenu au moyen de ce procédé, laquelle contient peu de FIXa et est très sûre. L'activateur de facteur IX de coagulation sanguine susmentionné est une sérine protéase 1 associée à la lectine et se liant avec le mannose (MASP-1). De préférence, l'activateur de facteur IX de coagulation sanguine est éliminé par chromatographie hydrophobe.
(JA)  血液凝固IX因子含有画分から血液凝固IX因子活性化因子を除去することによって活性化血液凝固IX因子の生成を防ぐことを特徴とする血液凝固IX因子の精製方法、および当該精製方法によって得られたFIXaの含有量の少ない安全性の高い血液凝固IX因子製剤を提供する。当該血液凝固IX因子活性化因子はマンノース結合レクチン結合性セリンプロテアーゼ−1(MASP-1)である。血液凝固IX因子活性化因子の除去は疎水クロマトグラフィーにより行うのが好ましい。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)