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1. (WO2005033063) MELANIN CONCENTRATING HORMONE ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/033063    International Application No.:    PCT/US2004/031631
Publication Date: 14.04.2005 International Filing Date: 24.09.2004
IPC:
C07C 233/79 (2006.01), C07D 295/135 (2006.01), A61K 31/166 (2006.01), A61K 31/4453 (2006.01), A61K 31/04 (2006.01)
Applicants: THE PROCTER & GAMBLE COMPANY [US/US]; One Procter & Gamble Plaza, Cincinnati, OH 45202 (US) (For All Designated States Except US).
HU, Xiufeng, Eric [US/US]; (US) (For US Only)
Inventors: HU, Xiufeng, Eric; (US)
Common
Representative:
THE PROCTER & GAMBLE COMPANY; c/o T. David Reed, 6110 Center Hill Road, Cincinnati, OH 45224 (US)
Priority Data:
60/507,773 01.10.2003 US
60/536,640 15.01.2004 US
Title (EN) MELANIN CONCENTRATING HORMONE ANTAGONISTS
(FR) ANTAGONISTES DE L'HORMONE CONCENTRANT LA MELANINE
Abstract: front page image
(EN)The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provides a means for reducing body mass. The compounds of the present invention are selective against melanin concentrating hormone and do not have the pernicious side effects resulting from compounds which interact with other appetite related brain receptors. Formula(I) wherein J is a unit containing at least one substituted or unsubstituted aryl or heteroaryl ring; R is an amino unit having the formula (II). L and L1 are linking groups each of which independently has the formula (III). Z, Z1, and Z2 are each independently a unit selected from the group consisting of: i) -NR5-; ii) -O-; iii) -SO2-; iv) -NR5SO2-; and v) -SO2NR5-; each of the indices j are independently 0 or 1; the indices m and n are each, independently from 0 to 5.
(FR)L'invention concerne des composés qui peuvent servir de modérateurs de l'appétit chez les humains et les mammifères, ainsi qu'un moyen permettant de réduire la masse corporelle. Ces composés sont sélectifs contre l'hormone concentrant la mélanine et n'ont pas les effets secondaires pernicieux résultant de composés qui interagissent avec d'autres récepteurs du cerveau relatifs à l'appétit.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)