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Machine translation
1. (WO2005033049) METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/033049    International Application No.:    PCT/US2004/032243
Publication Date: 14.04.2005 International Filing Date: 30.09.2004
IPC:
C07D 471/04 (2006.01)
Applicants: TARO PHARMACEUTICALS U.S.A., INC. [US/US]; Three Skyline Drive, Hawthorne, NY 10532 (US) (For All Designated States Except US).
GUTMAN, Daniella [IL/IL]; (IL).
BAIDOSSI, Wael [IL/IL]; (IL).
CHERNYAK, Shimon [IL/IL]; (IL)
Inventors: GUTMAN, Daniella; (IL).
BAIDOSSI, Wael; (IL).
CHERNYAK, Shimon; (IL)
Agent: SPRADAU, Todd; Taro Pharmaceuticals U.S.A., Inc., Five Skyline Drive, Hawthorne, NY 10532 (US)
Priority Data:
60/507,557 01.10.2003 US
Title (EN) METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
(FR) PROCEDE DE PREPARATION DE 4-AMINO-1H-IMIDAZO(4,5-C)QUINOLINES ET SELS D'AJOUT ACIDES DE CELLES-CI
Abstract: front page image
(EN)The present invention provides a method of preparing a 4-(arylmethyl)amino-1H­-imidazo(4,5-c)quinoline of formula (4) by reacting an arylmethylamine of formula (3) with a 4-chloro-lH-imidazo(4,5-c)quinoline of formula (2). The present invention further provides a method of preparing an acid addition salt of formula (5) comprising the step of hydrolyzing a 4-(arylmethyl)amino- 1 H-imidazo(4,5-c)quinoline of formula (4) with a strong acid, HX The present invention further provides a method of preparing a 4­amino- 1H-imidazo(4,5-c)quinoline of formula (1) comprising the step of treating an acid 10 addition salt of formula (5) with a base.
(FR)L'invention concerne un procédé de préparation d'une 4-(arylméthyl)amino-1H--imidazo(4,5-c)quinoline de formule (4) consistant à faire réagir une arylméthylamine de formule (3) avec une 4-chloro-lH-imidazo(4,5-c)quinoline de formule (2). L'invention concerne également un procédé de préparation d'un sel d'ajout acide de formule (5) comprenant l'étape consistant à hydrolyser une 4-(arylméthyl)amino- 1 H-imidazo(4,5-c)quinoline de formule (4) au moyen d'un acide fort, HX. L'invention concerne également un procédé de préparation d'une 4-amino- 1H-imidazo(4,5-c)quinoline de formule (1) comprenant l'étape consistant à traiter un sel d'ajout acide de formule (5) au moyen d'une base.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)