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1. (WO2005032580) METHODS AND COMPOSITIONS FOR TREATING EOSINOPHIL MEDIATED GASTRO-INTESTINAL DYSFUNCTION OR DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/032580    International Application No.:    PCT/AU2004/001380
Publication Date: 14.04.2005 International Filing Date: 08.10.2004
IPC:
A61K 38/47 (2006.01), A61P 1/04 (2006.01)
Applicants: THE AUSTRALIAN NATIONAL UNIVERSITY [AU/AU]; Acton, ACT 0200 (AU) (For All Designated States Except US).
HOGAN, Simon [AU/AU]; (AU) (For US Only)
Inventors: HOGAN, Simon; (AU)
Agent: SPRUSON & FERGUSON; GPO Box 3898, Sydney, NSW 2001 (AU)
Priority Data:
2003905553 08.10.2003 AU
Title (EN) METHODS AND COMPOSITIONS FOR TREATING EOSINOPHIL MEDIATED GASTRO-INTESTINAL DYSFUNCTION OR DISEASE
(FR) PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE DYSFONCTIONNEMENTS OU DE MALADIES GASTRO-INTESTINAUX D'ORIGINE EOSINOPHILE
Abstract: front page image
(EN)The present invention provides methods and compositions for the effective treatment of gastro-intestinal dysfunction, including chronic and acute inflammatory bowel diseases and the symptoms thereof, through the modulation of eosinophil peroxidase activity. The methods and compositions disclosed include those that modulate eosinophil peroxidase activity by depleting substrate, antagonizing enzyme activity, or attenuating enzyme expression so as to effect treatment of disease conditions or symptoms. Also provided are methods for the identification of additional therapeutically effective compounds for the treatment of gastro-intestinal dysfunction through the modulation of eosinophil peroxidase activity.
(FR)L'invention concerne des procédés et des compositions permettant de traiter efficacement un dysfonctionnement gastro-intestinal, y compris les maladies intestinales chroniques et aiguës et leurs symptômes, par une modulation de l'activité de l'éosinophile peroxidase. Les procédés et les compositions décrits permettent de moduler l'activité de l'éosinophile peroxidase par l'appauvrissement du substrat, la production d'un effet antagoniste à l'activité enzymatique ou l'atténuation de l'expression enzymatique, afin de traiter la maladie ou les symptômes pathologiques. L'invention concerne aussi des procédés visant à identifier d'autres composés thérapeutiquement efficaces pour traiter un dysfonctionnement gastro-intestinal par une modulation de l'activité de l'éosinophile peroxidase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)