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Machine translation
1. (WO2005032527) BENZO (4, 5) THIENO (2, 3-D) PYRIMIDIN-4-ONES AND THEIR USE IN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/032527    International Application No.:    PCT/EP2004/006230
Publication Date: 14.04.2005 International Filing Date: 09.06.2004
Chapter 2 Demand Filed:    04.07.2005    
IPC:
A61K 31/519 (2006.01), C07D 495/04 (2006.01)
Applicants: SOLVAY PHARMACEUTICALS B.V. [NL/NL]; C.J. van Houtenlaan 36, NL-1381 CP Weesp (NL)
Inventors: HIRVELÄ, Leena; (FI).
JOHANSSON, Nina; (FI).
KOSKIMIES, Pasi; (FI).
PENTIKÄINEN, Olli Taneli; (FI).
NYRÖNEN, Tommi; (FI).
SALMINEN, Tiina Annamaria; (FI).
JOHNSON, Mark Stuart; (FI).
LEHTOVUORI, Pekka; (FI)
Agent: GOSMANN, Martin; c/o Intellectual Property & Scientific Information, Solvay Pharmaceuticals GmbH, Hans Böckler Allee 20, 30173 Hannover (DE)
Priority Data:
60/477,047 10.06.2003 US
Title (EN) BENZO (4, 5) THIENO (2, 3-D) PYRIMIDIN-4-ONES AND THEIR USE IN THERAPY
(FR) NOUVEAUX COMPOSÉS ET LEUR UTILISATION EN THÉRAPIE
Abstract: front page image
(EN)This invention relates to benzo (4, 5) thieno (2, 3-d) pyrimidin-4-one compounds, their 5,6-dihydro and 5, 6, 7, 8-tetrahydro derivatives and their use for the treatment of a steroid hormone dependent disease or disorder, preferably for a steroid hormone dependent disease or disorder requiring the inhibition of a 17-hydroxysteroid dehydrogenase enzyme, most preferably of the 17beta HSD type 1, type 2 or type 3 enzyme. The steroid hormone dependent disease of disorder is selected from the group consisting of breast cancer, prostate carcinoma, ovarioan cancer, uterine cancer, endometrial cancer and endometrial hyperplasia, endometriosis, uterine fibroids, uterine leiomyoma, adenomyosis, dysmenorrhea, menorrhagia, metrorrhagia, prostadynia, benign prostatic hyperplasia, prostatitis, acne, seborrhea, hirsutism, androgenic alopecia, precocious puberty, adrenal hyperplasia, polycystic ovarian syndrome, urinary dysfunction, osteoporosis, multiple sclerosis, rheumatoid arthritis, Alzheimer’s disease, colon cancer, tissue wounds, skin wrinkles and cataracts.
(FR)Cette invention se rapporte à de nouveaux dérivés thiophènepyrimidinone et à leur utilisation en thérapie, notamment dans le traitement et/ou la prévention des maladies ou des troubles dépendant de l'hormone stéroïde, tels que les maladies ou les troubles dépendant de l'hormone stéroïde nécessitant l'inhibition des enzymes 17ß-hydroxystéroïdr-déshydrogénases.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)