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1. (WO2005032469) METHODS FOR REGULATING BUD-HYPHA TRANSITION AND cAMP LEVELS IN CANDIDA ALBICANS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/032469 International Application No.: PCT/US2004/031865
Publication Date: 14.04.2005 International Filing Date: 29.09.2004
IPC:
A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants: SUNDSTROM, Paula[US/US]; US (UsOnly)
TRUSTEES OF DARTMOUTH COLLEGE[US/US]; Technology Transfer Office 11 Rope Ferry Road Hanover, NH 03755-1404, US (AllExceptUS)
Inventors: SUNDSTROM, Paula; US
Agent: LICATA, Jane, Massey ; Licata & Tyrrell P.C. 66 E. Main Street Marlton, NJ 08053, US
Priority Data:
10/672,07429.09.2003US
Title (EN) METHODS FOR REGULATING BUD-HYPHA TRANSITION AND cAMP LEVELS IN CANDIDA ALBICANS
(FR) PROCEDES POUR REGULER LA TRANSITION BUD-HYPHA ET DES NIVEAUX DE CAMPS DANS LES CANDIDA ALBICANS
Abstract:
(EN) The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anticancer therapy.
(FR) L'infection d'un hôte mammifère par un micro-organisme peut être empêché ou traité par la modification de l'homologue C. albicans de la phosphodiestérase haute affinité, PDE2, un gène et/ou le gène de la protéine associée à l'adénylate cyclase. Lesdits procédés peuvent être utilisés dans l'identification, la prévention, ou le traitement d'infections microbiennes d'hôtes mammifères tels que des humains immunocompromis ou immunosupprimés, par exemple, les personnes atteintes du SIDA ou subissant une transplantation ou une thérapie anticancéreuse.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)