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1. (WO2005030945) NEW ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/030945 International Application No.: PCT/EP2004/010386
Publication Date: 07.04.2005 International Filing Date: 16.09.2004
IPC:
C12N 9/10 (2006.01)
Applicants: GOLZ, Stefan[DE/DE]; DE (UsOnly)
BRÜGGEMEIER, Ulf[DE/DE]; DE (UsOnly)
WEINGÄRTNER, Bernhard[DE/DE]; DE (UsOnly)
GEERTS, Andreas[DE/DE]; DE (UsOnly)
BAYER HEALTHCARE AG[DE/DE]; 51368 Leverkusen, DE (AllExceptUS)
Inventors: GOLZ, Stefan; DE
BRÜGGEMEIER, Ulf; DE
WEINGÄRTNER, Bernhard; DE
GEERTS, Andreas; DE
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing 51368 Leverkusen, DE
Priority Data:
03021637.826.09.2003EP
Title (EN) NEW ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF
(FR) NOUVELLE PROTEINE MGAT-X1 DE TYPE ACYLGLYCEROL ACYLTRANSFERASE ET SES UTILISATIONS
Abstract:
(EN) The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.
(FR) La présente invention concerne une séquence polynucléotidique d'une nouvelle protéine MGAT-X1 de type acylglycérol acyltransférase. La présente invention concerne également la protéine MGAT-X1 humaine associée aux maladies dermatologiques, aux maladies urologiques, aux troubles squeletto-musculaires, aux maladies hématologiques, au cancer, aux troubles de la reproduction, aux maladies neurologiques, aux maladies métaboliques, aux maladies cardiovasculaires ou aux maladies gastro-entérologiques. La présente invention concerne également des dosages permettant d'identifier des composés utilisés pour moduler des maladies dermatologiques, des maladies urologiques, des troubles squeletto-musculaires, des maladies hématologiques, le cancer, des troubles de la reproduction, des maladies neurologiques, des maladies métaboliques, des maladies cardiovasculaires ou des maladies gastro-entérologiques, afin de traiter ces maladies qui sont associées à l'expression de la protéine MGAT-X1. En outre, cette invention concerne des composés qui se lient et/ou activent ou inhibent l'activité de la protéine MGAT-X1, ainsi que des compositions pharmaceutiques comprenant de tels composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)