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1. (WO2005030787) OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATING DISEASE INCLUDING INFLAMMATORY CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/030787 International Application No.: PCT/CA2004/001765
Publication Date: 07.04.2005 International Filing Date: 29.09.2004
IPC:
A61K 38/00 (2006.01) ,C07H 21/00 (2006.01) ,C12N 15/11 (2006.01)
Applicants: RENZIE, Paolo[CA/CA]; CA (UsOnly)
ZEMZOUMI, Khalid[MA/CA]; CA (UsOnly)
D'ANJOU, Hélène[CA/CA]; CA (UsOnly)
TOPIGEN PHARMACEUTIQUE INC.[CA/CA]; 2901 Rachel Street Suite 13 Montreal, Québec H1W 4A4, CA (AllExceptUS)
Inventors: RENZIE, Paolo; CA
ZEMZOUMI, Khalid; CA
D'ANJOU, Hélène; CA
Agent: OGILVY RENAULT LLP / S.E.N.C.R.L., S.R.L.; Suite 1600 1981 McGill College Avenue Montreal, Québec H3A 2Y3, CA
Priority Data:
60/507,01629.09.2003US
Title (EN) OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATING DISEASE INCLUDING INFLAMMATORY CONDITIONS
(FR) COMPOSITIONS OLIGONUCLEOTIDIQUES ET PROCEDES DE TRAITEMENT DE MALADIES ASSOCIEES A UN ETAT INFLAMMATOIRE
Abstract: front page image
(EN) The invention relates to therapeutic antisense oligonucleotides directed against genes coding for phosphodiesterase (PDEs) and the use of these in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial.
(FR) L'invention concerne des oligonucléotides antisens thérapeutiques dirigés contre des gènes codant la phosphodiestérase (PDE), ainsi que leur utilisation combinée. Ces oligonucléotides antisens peuvent servir d'outils analytiques et/ou d'agents thérapeutiques dans le traitement d'une maladie associée à un taux d'AMPc cellulaire réduit chez un patient, telle qu'une maladie inflammatoire des voies respiratoires comme l'asthme, la maladie obstructive respiratoire chronique (COPD), le syndrome respiratoire aigu sévère, la bronchite, la bronchite chronique, la silicose, la fibrose pulmonaire, le rejet de greffe allogénique pulmonaire, la rhinite allergique et la sinusite chronique, ainsi que d'autres états pathologiques où une augmentation du taux d'AMP cyclique et une diminution des taux de PDE sont bénéfiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)