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1. (WO2005030259) NUCLEIC ACID-LIPOPHILIC CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/030259    International Application No.:    PCT/US2004/031748
Publication Date: 07.04.2005 International Filing Date: 27.09.2004
IPC:
A61K 47/48 (2006.01), C12N 15/88 (2006.01)
Applicants: COLEY PHARMACEUTICAL GROUP, INC. [US/US]; 93 Worcester Street, Suite 101, Wellesley, MA 02481 (US) (For All Designated States Except US).
COLEY PHARMACEUTICAL GmbH [DE/DE]; Elisabeth-Selbert-Strasse 9, 40764 Langenfeld (DE) (For All Designated States Except US).
VOLLMER, Joerg [DE/DE]; (DE) (For US Only).
KRIEG, Arthur, M. [US/US]; (US) (For US Only).
UHLMANN, Eugen [DE/DE]; (DE) (For US Only)
Inventors: VOLLMER, Joerg; (DE).
KRIEG, Arthur, M.; (US).
UHLMANN, Eugen; (DE)
Agent: LOCKHART, Helen, C.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210 (US)
Priority Data:
60/505,977 25.09.2003 US
Title (EN) NUCLEIC ACID-LIPOPHILIC CONJUGATES
(FR) CONJUGUES LIPOPHILES D'ACIDES NUCLEIQUES
Abstract: front page image
(EN)The present invention relates in part to immunostimulatory nucleic acids linked to a lipophilic group. It has been deiscovered that specific immunostimulatory nucleic acids linked to lipophilic groups have enhanced activity, whereas the linkage of lipophilic groups to other immunostimulatory nucleic acids has minimal effect on the immunostimulatory capability of the molecule.
(FR)L'invention concerne des conjugués lipophiles d'acides nucléiques, ainsi que des méthodes de modulation de réponse immunitaire mettant en oeuvre lesdits conjugués. L'invention concerne également le groupe fonctionnel lipophile associé à un acide nucléique immunostimulateur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)