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1. (WO2005030222) 1,3-DIACLYATED,26,27-ALKYL/HALOALKYL VITAMIN D3 COMPOUNDS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/030222 International Application No.: PCT/US2004/031412
Publication Date: 07.04.2005 International Filing Date: 24.09.2004
IPC:
A61K 31/59 (2006.01) ,C07C 401/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
59
Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
401
Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Applicants:
USKOKOVIC, Milan, R. [US/US]; US (UsOnly)
ADORINI, Luciano [IT/IT]; IT (UsOnly)
PENNA, Giuseppe [IT/IT]; IT (UsOnly)
COLLI, Enrico [IT/IT]; IT (UsOnly)
MAEHR, Hubert [US/US]; US (UsOnly)
BIOXELL S.P.A. [IT/IT]; via Olgettina 58 I-20132 Milano, IT (AllExceptUS)
Inventors:
USKOKOVIC, Milan, R.; US
ADORINI, Luciano; IT
PENNA, Giuseppe; IT
COLLI, Enrico; IT
MAEHR, Hubert; US
Agent:
LAURO, Peter, C.; Edwards & Angell, LLP P.O. Box 55874 Boston, MA 02205, US
Priority Data:
0322395.524.09.2003GB
0404567.001.03.2004GB
60/505,73524.09.2003US
Title (EN) 1,3-DIACLYATED,26,27-ALKYL/HALOALKYL VITAMIN D3 COMPOUNDS AND METHODS OF USE THEREOF
(FR) COMPOSES DE LA VITAMINE D3 1,3-DIACLYATEE,26,27-ALKYLE/HALOALKYLE ET PROCEDES D'UTILISATION ASSOCIES
Abstract:
(EN) The invention provides (1,3)di-acylated vitamin D3 analogs of cholecalciferol, substituted at carbon (20) with methyl or cyclopropyl wherein carbon (16) is a single or double bond, and carbon (23) is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon (25). The invention provides pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.
(FR) L'invention concerne des analogues de la vitamine D3 (1,3)di-acylatée de cholécalciférol, substitué sur le carbone (20) par du méthyle ou du cyclopropyle, le carbone (16) étant en liaison simple ou double, et le carbone (23) est une liaison simple, double ou triple. De nombreuses substitutions d'alkyle ou d'haloalkyle sont incorporés dans le carbone (25). L'invention concerne des esters pharmaceutiquement acceptables, leurs sels ou leurs promédicaments. L'invention concerne également des procédés pour utiliser les composés dans le traitement des états pathologiques associés à la vitamine D3, et des compositions pharmaceutiques contenant lesdits composés.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)