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1. (WO2005030040) HEMATOPOIETIC STEM CELL IDENTIFICATION AND ISOLATION

Pub. No.:    WO/2005/030040    International Application No.:    PCT/US2004/031677
Publication Date: Fri Apr 08 01:59:59 CEST 2005 International Filing Date: Tue Sep 28 01:59:59 CEST 2004
IPC: C12N 5/00
G01N 33/567
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
YILMAZ, Omer, H.
KIEL, Mark, J.
MORRISON, Sean
IWASHITA, Toshihide
Inventors: YILMAZ, Omer, H.
KIEL, Mark, J.
MORRISON, Sean
IWASHITA, Toshihide
Title: HEMATOPOIETIC STEM CELL IDENTIFICATION AND ISOLATION
Abstract:
The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48- HSCs, andCD244- HSCs. The present invention also relates to purified cell samples with enriched CD 150+ HSCs, CD48' HSCs, andCD244' HSCs populations, as well as methods of treating subjects with such compositions.