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1. WO2005026135 - METHOD FOR THE PRODUCTION OF 4-(4-AMINOPHENYL)-3-MORPHOLINON

Publication Number WO/2005/026135
Publication Date 24.03.2005
International Application No. PCT/EP2004/010054
International Filing Date 09.09.2004
IPC
B01D 9/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
9Crystallisation
B01J 23/44 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
23Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/113
38of noble metals
40of the platinum group metals
44Palladium
C07D 265/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
041,3-Oxazines; Hydrogenated 1,3-oxazines
12condensed with carbocyclic rings or ring systems
C07D 265/32 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
30not condensed with other rings
32with oxygen atoms directly attached to ring carbon atoms
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 265/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
30not condensed with other rings
32with oxygen atoms directly attached to ring carbon atoms
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • BAYER HEALTHCARE AG [DE]/[DE] (AllExceptUS)
  • THOMAS, Christian [DE]/[DE] (UsOnly)
  • BERWE, Mathias [DE]/[DE] (UsOnly)
  • STRAUB, Alexander [DE]/[DE] (UsOnly)
Inventors
  • THOMAS, Christian
  • BERWE, Mathias
  • STRAUB, Alexander
Common Representative
  • BAYER HEALTHCARE AG
Priority Data
103 42 570.515.09.2003DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN ZUR HERSTELLUNG VON 4-(4-AMINOPHENYL)-3-MORPHOLINON
(EN) METHOD FOR THE PRODUCTION OF 4-(4-AMINOPHENYL)-3-MORPHOLINON
(FR) PROCEDE DE PRODUCTION DE 4-(4-AMINOPHENYL)-3-MORPHOLINONE
Abstract
(DE) Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon durch Umsetzung von 4-(4-Nitrophenyl)-3-morpholinon mit Wasserstoff in Gegenwart eines Hydrierungskatalysators, dadurch gekennzeichnet, dass die Umsetzung in einem aliphatischen Alkohol erfolgt.
(EN) The invention relates to a method for the production of 4-(4-aminophenyl)-3-morpholinon by reacting 4-(4-nitrophenyl)-3-morpholinon with hydrogen in the presence of a hydrogenation catalyst. The invention is characterised in that the reaction is carried out in an aliphatic alcohol.
(FR) Procédé de production de 4-(4-aminophényl)-3-morpholinone par mise en réaction de 4-(4-nitrophényl)-3-morpholinone avec de l'hydrogène en présence d'un catalyseur d'hydrogénation, caractérisé en ce que la mise en réaction se produit dans un alcool aliphatique.
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