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1. WO2005026129 - PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES

Publication Number WO/2005/026129
Publication Date 24.03.2005
International Application No. PCT/EP2004/010353
International Filing Date 15.09.2004
IPC
C07D 239/42 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 239/48 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
48Two nitrogen atoms
C07D 401/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C04B 35/632
CCHEMISTRY; METALLURGY
04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE
35Shaped ceramic products characterised by their composition
622Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
626Preparing or treating the powders individually or as batches
63using additives specially adapted for forming the products ; , e.g.. binder binders
632Organic additives
C07D 239/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 239/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
48Two nitrogen atoms
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • GPC BIOTECH AG [DE]/[DE] (AllExceptUS)
  • SIMPSON, Don (UsOnly)
Inventors
  • SIMPSON, Don
  • CHOIDAS, Axel
  • BACKES, Alexander
  • COTTEN, Matt
  • ENGKVIST, Ola
  • FELBER, Beatrice
  • FREISLEBEN, Achim
  • GODL, Klaus
  • GREFF, Zoltán
  • HABENBERGER, Peter
  • HAFENBRADL, Doris
  • HARTUNG, Christian
  • HERGET, Thomas
  • HOPPE, Edmund
  • KLEBL, Bert
  • MISSIO, Andrea
  • MÜLLER, Gerhard
  • SCHWAB, Wilfried
  • ZECH, Birgit
  • BRAVO, Jose
  • HARRIS, John
  • LE, Joelle
  • MACRITCHIE, Jackie
  • SAVIC, Vladimir
  • SHERBORNE, Brad
  • SIMPSON, Don
Agents
  • ARTH, Hans-Lothar
Priority Data
03020888.815.09.2003EP
04010308.730.04.2004EP
60/504,52722.09.2003US
60/569,80612.05.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES
(FR) DERIVES D'AMINOPYRIMIDINE A DISUBSTITUTION 4,6 ACTIFS SUR LE PLAN PHARMACEUTIQUE EN TANT QUE MODULATEURS DES PROTEINE KINASES
Abstract
(EN) The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furhtermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.
(FR) Dérivés d'aminopyrimidine à disubstitution 4,6 et / ou sels desdits dérivés acceptables sur le plan pharmaceutique, utilisation de ces dérivés en tant qu'agents actifs sur le plan pharmaceutique, en particulier pour la prophylaxie et / ou le traitement de maladies infectieuses, dont des maladies opportunistes, de maladies à prion, de maladies immunologiques, de maladies autoimmunes, de troubles bipolaires et cliniques, de maladies cardio-vasculaires, de maladies à prolifération cellulaire, du diabète, de l'inflammation, des rejets après transplantation, du dysfonctionnement érectile, de maladies neurodégénératives et de l'accident vasculaire cérébral, et compositions pharmaceutiques contenant au moins un desdits dérivés et / ou des sels acceptables sur le plan pharmaceutique de ces dérivés. La présente invention concerne en outre l'utilisation desdits dérivés d'aminopyrimidine à disubstitution 4,6 en tant qu'inhibiteurs d'une protéine kinase et un milieu comprenant au moins un desdits dérivés sous une forme immobilisée et l'utilisation de ce milieu pour enrichir, purifier et / ou appauvrir des protéines de liaison des nucléotides qui se lient aux dérivés d'aminopyrimidine à disubstitution 4,6 immobilisés.
Related patent documents
US2007191344This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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