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1. WO2005026126 - CRF ANTAGONISTS AND HETEROBICYCLIC COMPOUNDS

Publication Number WO/2005/026126
Publication Date 24.03.2005
International Application No. PCT/JP2004/013386
International Filing Date 08.09.2004
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 491/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/4353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
Applicants
  • 小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 中井 久郎 NAKAI, Hisao [JP]/[JP] (UsOnly)
  • 斎藤 哲二 SAITO, Tetsuji [JP]/[JP] (UsOnly)
  • 小櫃 徹夫 OBITSU, Tetsuo [JP]/[JP] (UsOnly)
  • 源 智秋 MINAMOTO, Chiaki [JP]/[JP] (UsOnly)
  • 吉田 真幸 YOSHIDA, Mayuki [JP]/[JP] (UsOnly)
  • 岸 昭宏 KISHI, Akihiro [JP]/[JP] (UsOnly)
  • 勝又 清至 KATSUMATA, Seishi [JP]/[JP] (UsOnly)
  • 片山 英夫 KATAYAMA, Hideo [JP]/[JP] (UsOnly)
Inventors
  • 中井 久郎 NAKAI, Hisao
  • 斎藤 哲二 SAITO, Tetsuji
  • 小櫃 徹夫 OBITSU, Tetsuo
  • 源 智秋 MINAMOTO, Chiaki
  • 吉田 真幸 YOSHIDA, Mayuki
  • 岸 昭宏 KISHI, Akihiro
  • 勝又 清至 KATSUMATA, Seishi
  • 片山 英夫 KATAYAMA, Hideo
Agents
  • 大家 邦久 OHIE, Kunihisa
Priority Data
2003-31666209.09.2003JP
2004-12240919.04.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) CRF ANTAGONISTS AND HETEROBICYCLIC COMPOUNDS
(FR) ANTAGONISTES CRF ET COMPOSES HETEROBICYCLIQUES
(JA) CRF拮抗剤および二環式複素環化合物
Abstract
(EN) CRF antagonists containing as the active ingredient compounds represented by the general formula (I): (I) wherein A is an optionally substituted 5- or 6-membered monocycle; B is a 5- to 7-membered monocyclic unsaturated heterocycle which may additionally contain one or two heteroatoms and which may be additionally substituted; W1 and W2 are each carbon or nitrogen; Z is NR3, oxygen, optionally oxidized sulfur, or CR4R5; R1 is optionally substituted, alkyl, alkenyl, or alkynyl, optionally protected amino, optionally protected hydroxyl, optionally protected SH, S(O)nR6, COR7, or an optionally substituted cyclic group; and R2 is an unsaturated cyclic group which may be substituted.
(FR) L'invention concerne des antagonistes CRF contenant des composés actifs représentés par la formule (I) : (I), dans laquelle A est un monocycle à 5 ou 6 éléments éventuellement substitué, B est un hétérocycle monocyclique insaturé comportant 5 à 7 éléments, cet hétérocycle pouvant également contenir un ou deux hétéroatomes et éventuellement être substitué, W1 et W2 signifient chacun carbone ou azote, Z désigne NR3, oxygène, soufre éventuellement oxydé ou CR4R5, R1 est éventuellement substitué, alkyle, alcényle ou alcynyle, amino éventuellement protégé, hydroxyle éventuellement protégé, SH éventuellement protégé, S(O)nR6, COR7 ou un groupe cyclique éventuellement substitué, R2 représente un groupe cyclique insaturé pouvant être substitué.
(JA) not available
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