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1. WO2005023871 - AN AGENT FOR SELECTIVE SUPPRESSION DISEASE-ASSOCIATED AUTO-REACTIVE B-CELLS

Publication Number WO/2005/023871
Publication Date 17.03.2005
International Application No. PCT/BG2004/000010
International Filing Date 08.06.2004
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 9/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
9Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42against immunoglobulins (anti-idiotypic antibodies)
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07K 16/283
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
283against Fc-receptors, e.g. CD16, CD32, CD64
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • MINISTRY OF EDUCATION AND SCIENCE [BG]/[BG] (AllExceptUS)
  • VASSILEV, Tchavdar [BG]/[BG]
  • TCHORBANOV, Andrei [BG]/[BG]
  • MORITZ, Vihra [BG]/[BG]
Inventors
  • VASSILEV, Tchavdar
  • TCHORBANOV, Andrei
  • MORITZ, Vihra
Agents
  • STEFANOVA, Stanislava
Priority Data
10815504.09.2003BG
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AN AGENT FOR SELECTIVE SUPPRESSION DISEASE-ASSOCIATED AUTO-REACTIVE B-CELLS
(FR) AGENT POUR LA SUPPRESSION SELECTIVE DE LYMPHOCYTES B AUTOREACTIFS ASSOCIES A LA MALADIE
Abstract
(EN)
The invention relates to an agent for selective suppression of disease associated B-lymphocytes, more precisely of disease-associated DNA-specific B-cells in systemiclupus erythematosus. The agent is a bispecific chimeric monoclonal antibody capable of cross-linking an inhibitory and an immunoglobulin receptor on the surface of autoreactive B lymphocytes. According to the invention a method for production of the same chimeric antibody is disclosed.
(FR)
L'invention concerne un agent pour la suppression sélective de lymphocytes B associés à la maladie, et plus précisément les lymphocytes B spécifiques de l'ADN associés à la maladie dans le lupus érythémateux systémique. Il s'agit d'un anticorps monoclonal chimère bispécifique capable de fixer un récepteur inhibiteur et un récepteur d'immunoglobuline à la surface des lymphocytes B autoréactifs. On décrit également un procédé relatif à l'élaboration de cet anticorps.
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