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1. WO2005021566 - GLUCOPYRANOSYLOXY- PIRAZOLES, DRUGS CONTAINING SAID COMPOUNDS THE USE AND PRODUCTION METHOD THEREOF

Publication Number WO/2005/021566
Publication Date 10.03.2005
International Application No. PCT/EP2004/009332
International Filing Date 20.08.2004
IPC
C07H 17/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
02Heterocyclic radicals containing only nitrogen as ring hetero atoms
CPC
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
A61P 19/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
Applicants
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE]/[DE] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE]/[DE] (DE)
  • HIMMELSBACH, Frank [DE]/[DE] (UsOnly)
  • EICKELMANN, Peter [DE]/[DE] (UsOnly)
  • THOMAS, Leo [DE]/[DE] (UsOnly)
  • BARSOUMIAN, Edward Leon [US]/[JP] (UsOnly)
Inventors
  • HIMMELSBACH, Frank
  • EICKELMANN, Peter
  • THOMAS, Leo
  • BARSOUMIAN, Edward Leon
Common Representative
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Priority Data
10339549.026.08.2003DE
10359960.618.12.2003DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) GLUCOPYRANOSYLOXY-PYRAZOLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
(EN) GLUCOPYRANOSYLOXY- PIRAZOLES, DRUGS CONTAINING SAID COMPOUNDS THE USE AND PRODUCTION METHOD THEREOF
(FR) PYRAZOLES GLUCOPYRANOSYLOXY, MEDICAMENTS CONTENANT CES COMPOSES, LEUR UTILISATION ET LEUR PROCEDE DE PRODUCTION
Abstract
(DE) Die vorliegende Erfindung betrifft Glucopyranosyloxy-pyrazole der allgemeinen Formel (I), in der R1 bis R6 sowie R7a, R7b, R7c im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren, welche wertvolle pharmakologische Eigenschaften aufweisen, insbesondere eine Hemmwirkung auf den natriumabhängigen Glucose-Cotransporter SGLT, deren Verwendung zur Behandlung von Krankheiten, insbesondere von Stoffwechselerkrankungen wie Diabetes und deren Herstellung.
(EN) The invention relates to glucopyranosyloxy-pirazoles of formula (I), wherein R1 to R6 and R7a, R7b and R7c are defined in the claim 1, to the tautomers, stereoisomers, mixtures and the salts thereof, in particular the salts which are physiologically compatible with inorganic or organic acids and exhibit interesting pharmacological properties, in particular inhibitor effect on a sodium-dependent SGLT glucose cotransporter. The use of the inventive compounds for treating diseases, in particular metabolic diseases such as diabetes and the production thereof are also disclosed.
(FR) L'invention concerne des pyrazoles glucopyranosyloxy de formule (I), dans laquelle R1 à R6 ainsi que R7a, R7b, R7c sont définis dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges et leurs sels, notamment les sels physiologiquement compatibles avec des acides inorganiques ou organiques ayant des qualités pharmacologiques intéressantes, notamment un effet inhibiteur sur le co-transporteur de glucose SGLT dépendant du sodium. La présente invention porte également sur leur utilisation dans le traitement de maladies, notamment des maladies du métabolisme telles que le diabète, et sur leur production.
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