WO2005021505 THE CLAIMED INVENTION RELATES TO NOVEL 4-PIPERIDINECARBOXAMIDE AND THE USE THEREOF FOR THE PREPARATION OF MEDICAMENTS AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS

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Publication Number WO/2005/021505

Publication Date 10.03.2005

International Application No. PCT/SE2004/001236

International Filing Date 27.08.2004

Chapter 2 Demand Filed 24.03.2005

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Applicants

GALAPAGOS NV (AllExceptUS)
CROSSLEY, Roger [GB]/[GB] (UsOnly)
WARD, Terry [GB]/[GB] (UsOnly)
BERTHOLD, Malin [SE]/[SE] (UsOnly)

Inventors

CROSSLEY, Roger
WARD, Terry
BERTHOLD, Malin

Agents

BAKER-MUNTON, Nicola

Priority Data

0302369-4		03.09.2003		SE
60/505,295		23.09.2003		US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) THE CLAIMED INVENTION RELATES TO NOVEL 4-PIPERIDINECARBOXAMIDE AND THE USE THEREOF FOR THE PREPARATION OF MEDICAMENTS AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS

(FR) NOUVEAU 4-PIPERIDINE-CARBOXAMIDE ET LEUR UTILISATION POUR PREPARER DES MEDICAMENTS CONTRE DES TROUBLES LIES AU RECEPTEUR DE LA 5-HT2A

Abstract

(EN) The present invention relates to compounds of Formula (I) wherein R and R´ are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a 5-HT2A receptor-related disorder.

(FR) L'invention concerne des composés de formule (I), dans laquelle R et R' sont spécifiés dans la description, des procédés pour préparer les composés, des compositions pharmaceutiques comprenant lesdits composés, et l'utilisation de ces derniers dans la prophylaxie ou le traitement d'un trouble associé au récepteur de la 5-HT2A.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06	having no double bonds between ring members or between ring members and non-ring members
36	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
62	attached in position 4

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06	having no double bonds between ring members or between ring members and non-ring members
36	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
62	attached in position 4
66	having a hetero atom as the second substituent in position 4

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
403	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02	containing two hetero rings
06	linked by a carbon chain containing only aliphatic carbon atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06	having no double bonds between ring members or between ring members and non-ring members
36	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
62	attached in position 4

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06	having no double bonds between ring members or between ring members and non-ring members
36	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60	Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
62	attached in position 4
66	having a hetero atom as the second substituent in position 4

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1. WO2005021505 - THE CLAIMED INVENTION RELATES TO NOVEL 4-PIPERIDINECARBOXAMIDE AND THE USE THEREOF FOR THE PREPARATION OF MEDICAMENTS AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system