Processing

Please wait...

Settings

Settings

Goto Application

1. WO2005021486 - ESTER DERIVATIVE AND MEDICINAL USE THEREOF

Publication Number WO/2005/021486
Publication Date 10.03.2005
International Application No. PCT/JP2004/012407
International Filing Date 27.08.2004
IPC
C07C 233/81 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
81having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C07D 413/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • 日本たばこ産業株式会社 JAPAN TOBACCO INC. [JP]/[JP] (AllExceptUS)
  • 萩原 篤 HAGIWARA, Atsushi [JP]/[JP] (UsOnly)
  • 池ノ上 拓 IKENOGAMI, Taku [JP]/[JP] (UsOnly)
  • 米良 泰子 MERA, Yasuko [JP]/[JP] (UsOnly)
  • 住田 友香子 SUMIDA, Yukako [JP]/[JP] (UsOnly)
  • 飯田 聡夫 IIDA, Akio [JP]/[JP] (UsOnly)
  • 谷口 寿生 TANIGUCHI, Toshio [JP]/[JP] (UsOnly)
  • 高橋 満 TAKAHASHI, Mitsuru [JP]/[JP] (UsOnly)
Inventors
  • 萩原 篤 HAGIWARA, Atsushi
  • 池ノ上 拓 IKENOGAMI, Taku
  • 米良 泰子 MERA, Yasuko
  • 住田 友香子 SUMIDA, Yukako
  • 飯田 聡夫 IIDA, Akio
  • 谷口 寿生 TANIGUCHI, Toshio
  • 高橋 満 TAKAHASHI, Mitsuru
Agents
  • 岩谷 龍 IWATANI, Ryo
Priority Data
2003-30587729.08.2003JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) ESTER DERIVATIVE AND MEDICINAL USE THEREOF
(FR) DERIVE D'ESTER ET UTILISATION MEDICALE DE CELUI-CI
(JA) エステル誘導体及びその医薬用途
Abstract
(EN) A therapeutic agent for hyperlipemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also provided is an ester compound represented by the general formula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable salt thereof.
(FR) L'invention concerne un agent thérapeutique contre l'hyperlipémie n'ayant pas d'effets secondaires sur le foie, contrairement aux inhibiteurs des MTP classiques, et possédant une excellente activité d'inhibition des MTP. L'invention concerne également un composé d'ester représenté par la formule générale (1), ou un sel acceptable d'un point de vue pharmaceutique de celui-ci.
(JA)  従来のMTP阻害薬で見られるような肝臓に対する副作用がなく、しかも優れたMTPの阻害活性を有する高脂血症治療薬の提供。  一般式(1) 【化1】 で示されるエステル化合物又はその製薬上許容される塩。
Related patent documents
Latest bibliographic data on file with the International Bureau