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1. (WO2005017501) METHOD OF DIAGNOSING COLORECTAL ADENOMAS AND CANCER USING INFRARED SPECTROSCOPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/017501    International Application No.:    PCT/CA2004/001462
Publication Date: 24.02.2005 International Filing Date: 05.08.2004
IPC:
G01N 21/35 (2006.01), G01N 33/574 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL OF CANANDA [CA/CA]; 1200 Montreal Road, Ottawa, Ontario K1A 0R6 (CA) (For All Designated States Except US).
SMITH, Ian, C., P. [CA/CA]; (CA) (For US Only).
SOMORJAI, Ray, L. [CA/CA]; (CA) (For US Only).
MELTZER, Jon, C. [CA/CA]; (CA) (For US Only).
DOLENKO, Brion [CA/CA]; (CA) (For US Only).
NIKOULINE, Alexandre [CA/CA]; (CA) (For US Only)
Inventors: SMITH, Ian, C., P.; (CA).
SOMORJAI, Ray, L.; (CA).
MELTZER, Jon, C.; (CA).
DOLENKO, Brion; (CA).
NIKOULINE, Alexandre; (CA)
Agent: SEABY, George, A.; Seaby & Associates, 603 - 880 Wellington Street, Ottawa, Ontario K1R 6K7 (CA)
Priority Data:
60/494,781 14.08.2003 US
Title (EN) METHOD OF DIAGNOSING COLORECTAL ADENOMAS AND CANCER USING INFRARED SPECTROSCOPY
(FR) PROCEDE DE DIAGNOSTIC D'ADENOMES ET DU CANCER COLORECTAUX AU MOYEN DE LA SPECTROSCOPIE INFRAROUGE
Abstract: front page image
(EN)Infrared spectroscopy of human stool can be used as a non-invasive method of detecting the presence of colorectal cancer and/or clinically significant adenomas. The spectrum of a patient's stool is compared with that of stool from non-cancerous subjects, observed differences in spectra being indicative of cancer and/or clinically significant adenomas. In a preferred method, the stool sample is mixed with a buffer, the resulting suspension is centrifuged and the supernatant is subjected to infrared spectroscopy. The spectra are then classified using a three-stage classification strategy.
(FR)L'invention porte sur la spectroscopie infrarouge des selles humaines qui peut être utilisée en tant que procédé non invasif de détection de la présence du cancer colorectal et/ou d'adénomes cliniquement graves. Le spectre des selles d'un patient est comparé à celui des selles de sujets qui ne sont pas atteints de cancer, les différences observées dans les spectres indiquant un cancer et/ou des adénomes cliniquement graves. Dans un mode de réalisation préféré, l'échantillon de selles est mélangé à une solution tampon, la suspension obtenue étant centrifugée et le surnageant étant soumis à une spectroscopie infrarouge. Les spectres sont ensuite classés au moyen d'une stratégie de classification en trois étapes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)