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Pub. No.:    WO/2005/016928    International Application No.:    PCT/JP2004/011945
Publication Date: 24.02.2005 International Filing Date: 13.08.2004
Chapter 2 Demand Filed:    04.03.2005    
A61K 31/437 (2006.01), A61K 31/444 (2006.01), A61K 31/4545 (2006.01), A61K 31/465 (2006.01), A61K 31/497 (2006.01), A61K 31/501 (2006.01), A61K 31/506 (2006.01), A61K 31/5395 (2006.01), A61P 1/00 (2006.01), A61P 1/16 (2006.01), A61P 3/00 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01), A61P 3/10 (2006.01), A61P 5/00 (2006.01), A61P 9/00 (2006.01), A61P 9/04 (2006.01), A61P 9/10 (2006.01), A61P 9/12 (2006.01), A61P 11/00 (2006.01), A61P 13/12 (2006.01), A61P 15/00 (2006.01), A61P 15/06 (2006.01), A61P 17/00 (2006.01), A61P 19/00 (2006.01), A61P 25/02 (2006.01), A61P 25/08 (2006.01), A61P 25/14 (2006.01), A61P 25/20 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 25/30 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07D 471/04 (2006.01)
Applicants: BANYU PHARMACEUTICAL CO., LTD. [JP/JP]; 2-3, Nihombashi honcho 2-chome Chuo-ku, Tokyo 1038416 (JP) (For All Designated States Except US).
KISHINO, Hiroyuki [JP/JP]; (JP) (For US Only).
MORIYA, Minoru [JP/JP]; (JP) (For US Only).
SAKAMOTO, Toshihiro [JP/JP]; (JP) (For US Only).
TAKAHASHI, Hidekazu [JP/JP]; (JP) (For US Only).
SAKURABA, Shunji [JP/JP]; (JP) (For US Only).
SUZUKI, Takao [JP/JP]; (JP) (For US Only).
KANATANI, Akio [JP/JP]; (JP) (For US Only)
Inventors: KISHINO, Hiroyuki; (JP).
MORIYA, Minoru; (JP).
SAKAMOTO, Toshihiro; (JP).
TAKAHASHI, Hidekazu; (JP).
SAKURABA, Shunji; (JP).
SUZUKI, Takao; (JP).
BANYU PHARMACEUTICAL CO., LTD.; 2-3, Nihombashi honcho 2-chome, Chuo-ku, Tokyo 103-8416 (JP)
Priority Data:
2003-207632 15.08.2003 JP
(JA) イミダゾピリジン誘導体
Abstract: front page image
(EN)Imidazopyridine derivatives represented by the general formula [&Igr;]: [wherein R1 and R2 are each independently C1-6 alkyl or the like; R3 and R4 are each hydrogen, methyl, or the like; W is a mono- or bi-cyclic, 3- to 8-membered, aromatic or aliphatic heterocycle or the like; and Ar is an optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system diseases, circulatory diseases, and metabolic diseases.
(FR)L'invention concerne des dérivés d'imidazopyridines représentés par la formule générale [I]. Dans cette formule, R<sp>1</sp> et R<sp>2</sp> représentent chacun de façon indépendante un alkyle en C<sb>1-6</sb> ou analogue; R<sp>3</sp> et R<sp>4</sp> représentent chacun un hydrogène, un méthyle ou analogue; W représente un hétérocycle aliphatique ou aromatique, à 3 à 5 éléments, mono-orbi-cyclique ou analogue; et Ar représente un hétérocycle aromatique éventuellement substitué ou analogue. Ces composés agissent en tant qu'antagoniste de récepteur d'hormone concentrant la mélanine et sont utiles en tant que médicaments pour les maladies du système nerveux, les maladies circulatoires et les maladies métaboliques.
(JA) 一般式[I][式中、R及びRは、同一又は異なって、C1−6アルキル基等を表し、R及びRは、水素原子、メチル基等を表し、Wは、1又は2環性の3~8員の芳香族若しくは脂肪族複素環等を表し、Arは、置換基を有してもよい芳香族複素環等を表す。]で表されるイミダゾピリジン誘導体を提供する。この化合物は、メラニン凝集ホルモン受容体拮抗剤として作用し、中枢性疾患、循環器系疾患、代謝性疾患用の医薬品として有用である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)