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1. (WO2005016279) MELKS AS MODIFIERS OF THE RAC PATHWAY AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/016279 International Application No.: PCT/US2004/026231
Publication Date: 24.02.2005 International Filing Date: 12.08.2004
IPC:
G01N 33/53 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants: KADYK, Lisa[US/US]; US (UsOnly)
FRANCIS, George, Ross[US/US]; US (UsOnly)
HEUER, Timothy, S.[US/US]; US (UsOnly)
LICKTEIG, Kim[US/US]; US (UsOnly)
EXELIXIS, INC.[US/US]; 170 Harbor Way P.O. Box 511 South San Francisco, CA 94083-0511, US (AllExceptUS)
Inventors: KADYK, Lisa; US
FRANCIS, George, Ross; US
HEUER, Timothy, S.; US
LICKTEIG, Kim; US
Agent: SHAYESTEH, Laleh ; 170 Harbor Way P.O. Box 511 South San Francisco, CA 94083-0511, US
Priority Data:
60/495,19314.08.2003US
Title (EN) MELKS AS MODIFIERS OF THE RAC PATHWAY AND METHODS OF USE
(FR) MELKS UTILISES COMME MODIFICATEURS DU MECANISME D'ACTION DE RAC ET PROCEDES D'UTILISATION
Abstract:
(EN) Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.
(FR) Les gènes MELK humains sont identifiés comme étant des modulateurs du mécanisme d'action de RAC. Par conséquent, ils servent de cibles thérapeutiques pour soigner les troubles associés à un dysfonctionnement de RAC. Par ailleurs, l'invention concerne des procédés d'identification des modulateurs de RAC, qui consistent à cribler des agents modulant l'activité de MELK.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)