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1. (WO2005016229) USE OF LIPOPHILIC DIESTERS OF CHELATING AGENT FOR THE TREATMENT OF AMYLOIDOSIS AND ATHEROSCLEROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/016229 International Application No.: PCT/IL2004/000746
Publication Date: 24.02.2005 International Filing Date: 12.08.2004
IPC:
A61K 31/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
235
having an aromatic ring attached to a carboxyl group
24
having an amino or nitro group
Applicants: ROSENBERG, Gilad, Israel[IL/IL]; IL (UsOnly)
FRIEDMAN, Jonathan, Eduard[IL/IL]; IL (UsOnly)
ANGEL, Itzchak[IL/IL]; IL (UsOnly)
KOZAK, Alexander[IL/IL]; IL (UsOnly)
D-PHARM LTD.[IL/IL]; Kiryat Weizmann Science Park 76326 Rehovot, IL (AllExceptUS)
Inventors: ROSENBERG, Gilad, Israel; IL
FRIEDMAN, Jonathan, Eduard; IL
ANGEL, Itzchak; IL
KOZAK, Alexander; IL
Agent: WALKER, Naomi; Kiryat Weizmann Science Park P.O. Box 2313 76123 Rehovot, IL
Priority Data:
15739614.08.2003IL
Title (EN) USE OF LIPOPHILIC DIESTERS OF CHELATING AGENT FOR THE TREATMENT OF AMYLOIDOSIS AND ATHEROSCLEROSIS
(FR) UTILISATION DE DIESTERS LIPOPHILES D'UN AGENT DE CHELATION DANS LE TRAITEMENT DE L'AMYLOSE ET DE L'ATHEROSCLEROSE
Abstract:
(EN) The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid (BAPTA) for preventing, treating or managing atherosclerosis, amyloidosis-related diseases and disorders and other pathologies associated with proteins aggregations. In particular, these compounds are useful in treating cardiac and vascular amyloidosis, neurodegenerative diseases and disorders and cerebral amyloid angiopathy (CAA).
(FR) La présente invention concerne l'utilisation de diesters lipophiles de l'agent de chélation 1,2-bis(2 aminophénoxy)éthane-N,N,N'-acide tétraacétique (BAPTA) dans la prévention, le traitement ou la gestion de l'athérosclérose, des maladies et des troubles associés à l'amylose, et d'autres pathologies associées à l'agrégation des protéines. Ces composés sont utilisés, en particulier, dans le traitement de l'amylose cardiaque et vasculaire, des maladies et des troubles neurodégénératifs, et de l'angiopathie amyloïde cérébrale (CAA).
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)