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Machine translation
1. (WO2005016196) COMPOSITIONS AND METHODS FOR DESTABILIZING LYSOSOMES TO INCREASE ONCOGENIC OR ABERRANT PROTEIN DEGRADATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/016196    International Application No.:    PCT/US2004/024611
Publication Date: 24.02.2005 International Filing Date: 30.07.2004
IPC:
A61F 13/00 (2006.01)
Applicants: TRUSTEES OF DARTMOUTH COLLEGE [US/US]; Technology Transfer Office, 11 Rope Ferry Road, Hanover, NH 03755-1404 (US) (For All Designated States Except US).
KITAREEWAN, Sutisak [TH/US]; (US) (For US Only).
SLOBODA, Roger [US/US]; (US) (For US Only).
DMITROVSKY, Ethan [US/US]; (US) (For US Only)
Inventors: KITAREEWAN, Sutisak; (US).
SLOBODA, Roger; (US).
DMITROVSKY, Ethan; (US)
Agent: LICATA, Jane, Massey; Licata & Tyrrell P.C., 66 E. Main Street, Marlton, NJ 08053 (US)
Priority Data:
60/492,402 04.08.2003 US
Title (EN) COMPOSITIONS AND METHODS FOR DESTABILIZING LYSOSOMES TO INCREASE ONCOGENIC OR ABERRANT PROTEIN DEGRADATION
(FR) COMPOSITIONS ET PROCEDES POUR DESTABILISER LES LYSOSOMES AFIN D'ACCROITRE LA DEGRADATION DE PROTEINES ONCOGENES OU ABERRANTES
Abstract: front page image
(EN)The present invention relates to compositions and methods for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention and treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are agents identified in accordance with the screening method.
(FR)L'invention concerne des compositions et des procédés permettant de déstabiliser les lysosomes afin d'accroître la dégradation de protéines oncogènes ou aberrantes, ur prévenir et traiter une maladie. L'invention concerne aussi des procédés d'identification d'agents qui déstabilisent les lysosomes et les agents identifiés selon le procédé de criblage.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)