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1. (WO2005015988) NPC1L1 (NPC3) AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/015988    International Application No.:    PCT/US2003/040113
Publication Date: 24.02.2005 International Filing Date: 16.12.2003
IPC:
A01K 67/00 (2006.01), A01K 67/033 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US)
Inventors: ALTMANN, Scott, W.; (US).
MURGOLO, Nicholas, J.; (US).
WANG, Lu, Quan; (US).
GRAZIANO, Michael, P.; (US)
Agent: TRIOLO, Thomas, A.; SCHERING-PLOUGH CORPORATION, Patent Department, K-6-1 1990, 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US)
Priority Data:
10/621,758 17.07.2003 US
10/646,301 22.08.2003 US
10/663,208 16.09.2003 US
Title (EN) NPC1L1 (NPC3) AND METHODS OF USE THEREOF
(FR) NPC1L1 (NPC3) ET PROCEDES D'UTILISATION CORRESPONDANTS
Abstract: front page image
(EN)The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.
(FR)La présente invention concerne des polypeptides NPC1L1 humains, de rat et de souris ainsi que des polynucléotides codant ces polypeptides. Cette invention concerne également des procédés de détection d'agonistes et d'antagonistes de NPC1L1. Des inhibiteurs de NPC1L1 peuvent être utilisés pour inhiber une absorption intestinale du cholestérol chez un sujet.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, HR, HU, ID, IL, IN, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LU, LV, MA, MD, MG, MK, MN, MX, MZ, NI, NO, NZ, PG, PH, PL, PT, RO, RU, SC, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UZ, VC, VN, YU, ZA, ZM.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)