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Machine translation
1. (WO2005015155) METHODS FOR COMPARING RELATIVE FLUX RATES OF TWO OR MORE BIOLOGICAL MOLECULES IN VIVO THROUGH A SINGLE PROTOCOL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/015155    International Application No.:    PCT/US2004/020319
Publication Date: 17.02.2005 International Filing Date: 23.06.2004
IPC:
A61K 51/00 (2006.01), C07H 15/00 (2006.01), C07H 21/02 (2006.01), C07H 21/04 (2006.01), C12Q 1/00 (2006.01), C12Q 1/02 (2006.01), C12Q 1/68 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US) (For All Designated States Except US).
HELLERSTEIN, Marc, K. [US/US]; (US) (For US Only)
Inventors: HELLERSTEIN, Marc, K.; (US)
Agent: WARD, Michael, R.; Morrison & Foerster LLP, 425 Market Street, San Francisco, CA 94105-2482 (US)
Priority Data:
60/484,626 03.07.2003 US
Title (EN) METHODS FOR COMPARING RELATIVE FLUX RATES OF TWO OR MORE BIOLOGICAL MOLECULES IN VIVO THROUGH A SINGLE PROTOCOL
(FR) METHODES DE COMPARAISON DES DEBITS RELATIFS D'AU MOINS DEUX MOLECULES BIOLOGIQUES IN VIVO AU MOYEN D'UN SEUL PROTOCOLE
Abstract: front page image
(EN)The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, including biological molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing, or monitoring a disease, disorder, or condition, the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for toxic effects.
(FR)L'invention concerne des techniques permettant de mesurer et de comparer les débits moléculaires relatifs de différentes molécules biologiques. Ces techniques consistent à administrer de l'eau marquée par des isotopes à un ou plusieurs tissus ou sujets et à comparer les débits moléculaires d'au moins deux molécules biologiques, notamment des molécules biologiques dans différentes classes chimiques. Ces méthodes sont notamment utiles pour le diagnostic, le pronostic ou le monitorage d'une maladie, d'un trouble ou d'une affection, le criblage in vivo à haut rendement d'entités chimiques et les facteurs biologiques pour les effets toxiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)