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Machine translation
1. (WO2005014786) ENHANCED ENGINEERED CHROMOSOME FORMATION FROM ALPHA SATELLITE WITH ARTIFICIALLY INCREASED DENSITY OF CENP-B BOXES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/014786    International Application No.:    PCT/US2004/022314
Publication Date: 17.02.2005 International Filing Date: 09.08.2004
IPC:
C12N 15/66 (2006.01), C12N 15/85 (2006.01)
Applicants: ATHERSYS, INC. [US/US]; 3201 Carnegie Avenue, Cleveland, OH 44115 (US) (For All Designated States Except US).
VAN BOKKELEN, Gil, B. [--/US]; (US) (For US Only).
BASU, Joydeep [--/US]; (US) (For US Only)
Inventors: VAN BOKKELEN, Gil, B.; (US).
BASU, Joydeep; (US)
Agent: MCPHAIL, Donald, R.; Fleshner & Kim, LLP, P.O. Box 221200, Chantilly, VA 20153-1200 (US)
Priority Data:
60/492,965 07.08.2003 US
Title (EN) ENHANCED ENGINEERED CHROMOSOME FORMATION FROM ALPHA SATELLITE WITH ARTIFICIALLY INCREASED DENSITY OF CENP-B BOXES
(FR) FORMATION DE CHROMOSOMES TRANSGENIQUES AMELIOREE A PARTIR D'UN ADN ALPHA-SATELLITE PRESENTANT UNE DENSITE ARTIFICIELLEMENT ACCRUE DE BOITES CENP-B
Abstract: front page image
(EN)The invention relates to the discovery that the distribution of CENP-B boxes on the alpha-satellite DNA affects efficiency of the centromere and thereby, affects efficiency of chromosome formation. Therefore, engineered chromosome vectors with altered distribution of CENP-B boxes are described that can alter the rate of chromosome formation as desired. Engineered HORs, chromosome vectors, and chromosomes as well as methods of making the same are described and claimed.
(FR)L'invention concerne une découverte selon laquelle la répartition des boîtes CENP-B sur l'ADN alpha-satellite affecte l'efficacité du centromère, et, par conséquent, affecte l'efficacité de la formation des chromosomes. Ainsi, l'invention concerne des vecteurs chromosomiques transgéniques présentant une répartition modifiée des boîtes CENP-B, ce qui permet de modifier la vitesse de formation des chromosomes comme souhaité. L'invention concerne en outre des HOR, des vecteurs chromosomiques et des chromosomes transgéniques ainsi que des méthodes de fabrication correspondantes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)