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1. (WO2005014609) METHOD OF PRODUCING A HIGHLY STEREOREGULAR PHOSPHORUS ATOM-MODIFIED NUCLEOTIDE ANALOGUE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/014609 International Application No.: PCT/JP2004/011524
Publication Date: 17.02.2005 International Filing Date: 04.08.2004
IPC:
C07H 19/10 (2006.01) ,C07H 19/11 (2006.01) ,C07H 19/213 (2006.01) ,C07H 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
11
containing cyclic phosphate
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
213
containing cyclic phosphate
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants: SAIGO, Kazuhiko[JP/JP]; JP (UsOnly)
WADA, Takeshi[JP/JP]; JP (UsOnly)
TOUDAI TLO, LTD.[JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1130033, JP (AllExceptUS)
Inventors: SAIGO, Kazuhiko; JP
WADA, Takeshi; JP
Agent: FURUYA, Satoshi ; Hamacho-Hanacho Building 6th Floor, 2-17-8, Nihonbashi-Hamacho, Chuo-ku, Tokyo 1030007, JP
Priority Data:
2003-28955908.08.2003JP
2004-08915025.03.2004JP
Title (EN) METHOD OF PRODUCING A HIGHLY STEREOREGULAR PHOSPHORUS ATOM-MODIFIED NUCLEOTIDE ANALOGUE
(FR) PROCEDE DE PRODUCTION D'UN ANALOGUE DE NUCLEOTIDE HAUTEMENT STEREOREGULIER DONT L'ATOME DE PHOSPHORE EST MODIFIE
Abstract:
(EN) To provide an efficient production method for a highly stereoregular phosphorus atom-modified nucleotide where a conformation on a phosphorus atom is controlled. A production method for a highly stereoregular phosphorus atom-modified nucleotide analogue represented by the general formula (4) et (5), characterized by comprising condensing optically-active nucleoside 3’-phosphoramidite with nucleoside using an activator, followed by reaction with an electrophilic reagent and deprotection.
(FR) L'invention concerne un procédé de production d'un nucléotide hautement stéréorégulier dont l'atome de phosphore est modifié, dans lequel la conformation d'un atome de phosphore est modulée. Elle porte également sur un procédé de production d'un analogue de nucléotide hautement stéréorégulier dont l'atome de phosphore est modifié, représenté par la formule générale (4) ou (5), qui se caractérise en ce qu'il consiste à condenser un 3'-phosphoramidite de nucléoside optiquement actif avec un nucléoside, au moyen d'un activateur, puis à faire réagir un réactif électrophile et à déprotéger.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)