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1. (WO2005014572) PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/014572 International Application No.: PCT/EP2004/008853
Publication Date: 17.02.2005 International Filing Date: 06.08.2004
Chapter 2 Demand Filed: 08.06.2005
IPC:
A61K 31/506 (2006.01) ,A61K 31/513 (2006.01) ,A61K 31/52 (2006.01) ,A61K 41/00 (2006.01) ,A61K 45/06 (2006.01) ,C07D 471/04 (2006.01) ,C07D 519/00 (2006.01)
Applicants: VANOTTI, Ermes[CH/IT]; IT (UsOnly)
D'ALESSIO, Roberto[IT/IT]; IT (UsOnly)
TIBOLLA, Marcellino[IT/IT]; IT (UsOnly)
VARASI, Mario[IT/IT]; IT (UsOnly)
MONTAGNOLI, Alessia[IT/IT]; IT (UsOnly)
SANTOCANALE, Corrado[IT/IT]; IT (UsOnly)
ORSINI, Paolo[IT/IT]; IT (UsOnly)
PILLAN, Antonio[IT/IT]; IT (UsOnly)
PHARMACIA ITALIA S.P.A.[IT/IT]; Via Robert Koch 1.2 I-20152 Milano, IT (AllExceptUS)
Inventors: VANOTTI, Ermes; IT
D'ALESSIO, Roberto; IT
TIBOLLA, Marcellino; IT
VARASI, Mario; IT
MONTAGNOLI, Alessia; IT
SANTOCANALE, Corrado; IT
ORSINI, Paolo; IT
PILLAN, Antonio; IT
Agent: MODIANO, Micaela, Nadia; MODIANO JOSIF PISANTY & STAUB Baaderstrasse 3 D-80469 MUNICH, DE
Priority Data:
60/493,63308.08.2003US
Title (EN) PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
(FR) DERIVES DE PYRIMIDYLPYRROLE POUVANT ETRE UTILISES COMME INHIBITEURS DE KINASES
Abstract:
(EN) Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
(FR) L'invention concerne des dérivés de pyrimidylpyrrole représentés par la formule générale (1) ainsi que des sels de qualité pharmaceutiques de ces dérivés, tels qu'ils sont décrits dans la description, des procédés destinés à la préparation de ces dérivés et des compositions pharmaceutiques comprenant ces dérivés. Les composés de l'invention peuvent être utilisés pour le traitement de maladies associées à un dérèglement de l'activité de la protéine kinase, telles que le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)