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1. (WO2005014533) ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/014533    International Application No.:    PCT/US2004/025463
Publication Date: 17.02.2005 International Filing Date: 06.08.2004
IPC:
C07C 233/87 (2006.01), C07C 235/42 (2006.01), C07C 235/52 (2006.01), C07C 235/60 (2006.01), C07C 235/66 (2006.01), C07C 237/36 (2006.01), C07C 237/42 (2006.01), C07C 271/20 (2006.01), C07C 311/08 (2006.01), C07C 311/09 (2006.01), C07C 311/21 (2006.01), C07C 311/44 (2006.01), C07C 317/32 (2006.01), C07C 323/36 (2006.01), C07D 295/155 (2006.01)
Applicants: TRANSTECH PHARMA, INC. [US/US]; 4170 Mendenhall Oaks Parkway, Suite 110, High Point, North Carolina 27265 (US) (For All Designated States Except US).
MJALLI, Adnan, M.M. [US/US]; (US) (For US Only).
ANDREWS, Robert, C. [US/US]; (US) (For US Only).
GUO, Xiao-Chuan [CN/US]; (US) (For US Only).
CHRISTEN, Daniel, Peter [CH/US]; (US) (For US Only).
GOHIMMUKKULA, Devi, Reddy [IN/US]; (US) (For US Only).
HUANG, Guoxiang [CN/US]; (US) (For US Only).
ROTHLEIN, Robert [US/US]; (US) (For US Only).
TYAGI, Sameer [IN/US]; (US) (For US Only).
YARAMASU, Tripura [IN/US]; (US) (For US Only).
BEHME, Christopher [US/US]; (US) (For US Only)
Inventors: MJALLI, Adnan, M.M.; (US).
ANDREWS, Robert, C.; (US).
GUO, Xiao-Chuan; (US).
CHRISTEN, Daniel, Peter; (US).
GOHIMMUKKULA, Devi, Reddy; (US).
HUANG, Guoxiang; (US).
ROTHLEIN, Robert; (US).
TYAGI, Sameer; (US).
YARAMASU, Tripura; (US).
BEHME, Christopher; (US)
Agent: CALKINS, Charles, W.; Kilpatrick Stockton, LLP, 1001 West Fourth Street, Winston-Salem, North Carolina 27101 (US)
Priority Data:
60/493,903 08.08.2003 US
60/493,878 08.08.2003 US
60/493,879 08.08.2003 US
Title (EN) ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
(FR) COMPOSES ARYLE ET HETEROARYLE, COMPOSITIONS ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway..
(FR)La présente invention concerne des composés aryle et hétéroaryle, des procédés pour les préparer, des compositions pharmaceutiques comprenant ces composés, et leur utilisation pour traiter des troubles chez les êtres humains et chez les animaux. Les composés de l'invention peuvent être des antagonistes ou antagonistes partiels du facteur IX et/ou facteur XI et peuvent ainsi être utiles pour inhiber le passage intrinsèque de la coagulation sanguine. Les composés peuvent être utilisés dans différentes applications comprenant la gestion, le traitement et/ou la régulation de maladies causées en partie par le passage de coagulation intrinsèque.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)