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1. (WO2005014530) INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/014530    International Application No.:    PCT/US2004/025699
Publication Date: 17.02.2005 International Filing Date: 06.08.2004
IPC:
C07C 239/20 (2006.01), C07C 243/18 (2006.01)
Applicants: LA JOLLA PHARMACEUTICAL CO. [US/US]; 6455 Nancy Ridge Drive, Suite 300, San Diego, CA 92121 (US) (For All Designated States Except US).
SALTER-CID, Luisa, Maria [PT/US]; (US) (For US Only).
WANG, Eric, Yanjun [US/US]; (US) (For US Only).
COCKERILL, Keith [US/US]; (US) (For US Only).
LINNIK, Matthew, D. [US/US]; (US) (For US Only).
VICTORIA, Edward, J. [US/US]; (US) (For US Only)
Inventors: SALTER-CID, Luisa, Maria; (US).
WANG, Eric, Yanjun; (US).
COCKERILL, Keith; (US).
LINNIK, Matthew, D.; (US).
VICTORIA, Edward, J.; (US)
Agent: CERPA, Robert, K.; Morrison & Foerster LLP, 755 Page Mill Road, Palo Alto, CA 94304 (US)
Priority Data:
60/493,835 08.08.2003 US
60/502,401 12.09.2003 US
60/568,999 06.05.2004 US
Title (EN) INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
(FR) INHIBITEURS D'AMINE OXYDASE SENSIBLE AUX SEMICARBAZIDES (SSAO) ET ADHERENCE MEDIEE PAR LA VAP-1 UTILE POUR LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN)Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.
(FR)La présente invention se rapporte à des compositions et à des méthodes d'utilisation de compositions pour le traitement de maladies inflammatoires et de troubles immunitaires. L'invention se rapporte à des composés d'allylhydrazine, à des composés d'hydroxylamine (aminooxy), et à d'autres composés qui sont des inhibiteurs de l'amine oxydase sensible aux semicarbazides (SSAO) et/ou de la protéine 1 d'adhérence vasculaire (VAP-1). Ces composés présentent une utilité thérapeutique pour la suppression des inflammations et des réactions inflammatoires, et pour le traitement de plusieurs troubles, notamment de la sclérose en plaques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)